IP Library › Granted Patent US 8,871,769
Granted Patent B2
US 8,871,769 · App. 13/946,353 · Granted Oct 28, 2014

Ureas and their use in the treatment of heart failure

Inventors: Bradley Paul Morgan (Moraga, CA); Alex Muci (San Francisco, CA); Pu-Ping Lu (Foster City, CA); Erica Anne Kraynack (Belmont, CA); Todd Tochimoto (Foster City, CA); David J. Morgans (Los Altos, CA)
Assignee: Cytokinetics, Inc.
C07D213/75C07D513/04C07D295/26C07D417/00C07D401/12C07D491/04C07D271/113C07D239/42C07D487/04C07D261/14C07D211/56C07D263/48C07D401/10
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Quick Facts
Patent No.
US 8,871,769
App. No.
13/946,353
Granted
Oct 28, 2014
Kind
B2
Abstract

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Claims (2)

1. A composition comprising methyl-4-(2-fluoro-3-(6-methylpyridin-3-yl)benzyl)piperazine-1-carboxylate having the structure:

or a pharmaceutically acceptable salt thereof, and tetrahydrofuran.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 5, 2021
From: MORGAN, BRADLEY PAUL; MUCI, ALEX; LU, PU-PING; TOCHIMOTO, TODD; MORGANS, DAVID J., JR.; KRAYNACK, ERICA ANNE
To: CYTOKINETICS, INCORPORATED
Reel/Frame 057092/0366 →
Continuity (4)
Continuation 13341413 · Dec 30, 2011
Continuation 11630062
Provisional Application 60581197 · Jun 17, 2004
Related Publication 20140038983A1 · Feb 6, 2014