Calcium carbonate granulation
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
1. A dietary supplement tablet comprising an amount of calcium carbonate sufficient to provide about 600 mg of elemental calcium, said tablet being about 20% to about 35% smaller in volume than 1 cc, wherein said calcium carbonate is provided in compressed calcium carbonate granulations, wherein prior to compression into said tablet, said compressed calcium carbonate granulations are highly compactable and have a tap density between about 0.9 and about 2.0 g/cm 3 .
2. The tablet of claim 1 , wherein the tablet is about 20% smaller than 1 cc.
3. The tablet of claim 1 , wherein said compressed calcium carbonate granulations comprise USP or food grade calcium carbonate powder having a median particle diameter of about 20 μm.
4. The tablet of claim 1 , wherein said compressed calcium carbonate granulations comprise USP or food grade calcium carbonate powder having a median particle diameter from about 6 μm to about 12 μm.
5. The tablet of claim 1 , wherein said compressed calcium carbonate granulations comprise USP or food grade calcium carbonate powder having a median particle diameter from about 6 μm to about 10 μm.
6. The tablet of claim 1 , wherein said compressed calcium carbonate granulations comprise USP or food grade calcium carbonate powder having a median particle diameter of about 6 μm.
7. The tablet of claim 1 , further comprising a binder in said compressed calcium carbonate granulations.
8. The tablet of claim 7 , wherein the binder is maltodextrin.
9. The tablet of claim 8 , wherein said maltodextrin has a dextrose equivalent (DE) of 10.
10. The tablet of claim 9 , wherein said compressed calcium carbonate granulations comprise USP or food grade calcium carbonate powder having a median particle diameter of 0.1 μm to about 20 μm.
11. The tablet of claim 1 , wherein said compressed calcium carbonate granulations, prior to compression into said tablet, have a tap density between about 1.0 and about 2.0 g/cm 3 .
12. The tablet of claim 1 , wherein said compressed calcium carbonate granulations, prior to compression into said tablet, have a tap density between about 1.1 and about 2.0 g/cm 3 .
13. The tablet of claim 1 , wherein said compressed calcium carbonate granulations, prior to compression into said tablet, have sufficient compactability for compression into said tablet.
14. The tablet of claim 1 , wherein said compressed calcium carbonate granulations comprise 600 mg of elemental calcium.
15. The tablet of claim 1 , wherein said compressed calcium carbonate granulations, prior to compression into said tablet, is prepared by a process wherein a calcium carbonate powder and a binder are mixed with water under shear and drying said mixture in a fluidized bed.
16. The tablet of claim 15 , wherein said mixing under shear is carried out with an impeller blade operating at from about 200 to about 300 rpm.