Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
1. A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein;
m is 0;
each occurrence of n is independently an integer ranging from 3 to 7;
X is(CH 2 )z, wherein z is 0;
R 1 and R 2 and the carbon to which they are both attached are taken together to form a (C 3 -C 7 ) cycloakyl group;
R 11 and R 12 and the carbon to which they are both attached are taken together to form a (C 3 -C 7 ) cycloakyl group;
each occurrence of Y 1 and Y 2 is independently COOH or COOR 3 ; and
R 3 is (C 1 -C 6 )akyl.
2. The compound of claim 1 , wherein n is 5.
3. The compound of claim 2 , wherein Y 1 and Y 2 are COOH.
4. A compound having the following structure:
5. A compound having the following structure:
or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable vehicle.
7. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable vehicle.
8. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable vehicle.
9. A pharmaceutical composition comprising a compound of claim 4 and a pharmaceutically acceptable vehicle.
10. A pharmaceutical composition comprising a compound of claim 5 and a pharmaceutically acceptable vehicle.