Microfabricated instruments and methods to treat recurrent corneal erosions
In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.
1. A method of treating recurrent corneal erosion comprising:
contacting an epithelium layer of a cornea with an array of solid glass micro-rods including a plurality of sharp features having a penetrating length ranging from 10 microns to 20 microns that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of micro-rods produces a plurality of punctures in at least the Bowman's layer of the eye with a puncture diameter ranging from 1 micron to 10 microns.
2. The method of claim 1 , wherein the array of micro-rods features includes a plurality of sharp features ranging from about 400 to about 100,000 of said sharp features.
3. The method of claim 1 , wherein the contacting the epithelial layer includes puncturing through the epithelial layer and the Bowman layer into the stroma.
4. The method of claim 1 , wherein contacting the epithelium layer enhances epithelial cell attachment by inducing the formation of a new Bowman's layer overlying an area of a puncture by the plurality of sharp features and by forming fibrous adhesions to the epithelial layer.