Antibodies against human angiopoietin 2
The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
1. An isolated nucleic acid encoding an antibody which binds specifically to human angiopoietin-2 (ANG-2), wherein said antibody comprises:
(A) a heavy chain variable domain which comprises a CDR3 region having the sequence of SEQ ID NO: 33, a CDR2 region having the sequence of SEQ ID NO: 34 and a CDR1 region having the sequence of SEQ ID NO: 35; and
(B) a light chain variable domain which comprises a CDR3 region having the sequence of SEQ ID NO: 36, a CDR2 region having the sequence of SEQ ID NO: 37 and a CDR1 region having the sequence of SEQ ID NO: 38.
2. An expression vector characterized in comprising the isolated nucleic acid according to claim 1 for the expression of said antibody in a prokaryotic or eukaryotic host cell.
3. A prokaryotic or eukaryotic host cell comprising the vector according to claim 2 .
4. An isolated nucleic acid encoding an antibody which binds specifically to human ANG-2, wherein said antibody comprises a heavy chain variable domain which comprises SEQ ID NO: 39 and a light chain variable domain which comprises SEQ ID NO: 40.
5. An expression vector characterized in comprising the isolated nucleic acid according to claim 4 for the expression of said antibody in a prokaryotic or eukaryotic host cell.
6. A prokaryotic or eukaryotic host cell comprising the vector according to claim 5 .