IP Library Granted Patent US 9,242,981
Granted Patent B2
US 9,242,981 · App. 13/821,149 · Granted Jan 26, 2016

Fused pyrazole derivatives as novel ERK inhibitors

Inventors: Gerald W. Shipps, Jr. (Stoneham, MA); Yongqi Deng (Newton, MA); Alan B. Cooper (West Caldwell, NJ); Xiaolei Gao (Bridgewater, NJ); Binyuam Sun (Chestnut Hill, MA); James Wang (Westfield, NJ); Liang Zhu (Waltham, MA)
Assignee: Merck Sharp & Dohme Corp.
C07D471/04C07D401/04C07D401/14C07D405/04C07D405/14C07D409/14C07D417/14C07D519/00
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Quick Facts
Patent No.
US 9,242,981
App. No.
13/821,149
Granted
Jan 26, 2016
Kind
B2
Abstract

Disclosed are the ERK inhibitors of Formula (I): (Formula (I)) and the pharmaceutically acceptable salts thereof. All substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (I).

Claims (3)

1. A compound which is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising at least one compound of claim 1 and a pharmaceutically acceptable carrier.

Assignments (3)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 6, 2013
From: SHIPPS, GERALD W., JR.; DENG, YONGQI; COOPER, ALAN B.; GAO, XIAOLEI; SUN, BINYUAN; WANG, JAMES; ZHU, LIANG
To: SCHERING CORPORATION
Reel/Frame 029934/0720 →
CHANGE OF NAME Recorded Mar 6, 2013
From: SCHERING CORPORATION
To: MERCK SHARP & DOHME CORP.
Reel/Frame 029939/0722 →
Continuity (2)
Provisional Application 61383376 · Sep 16, 2010
Related Publication 20130172341A1 · Jul 4, 2013