IP Library › Granted Patent US 9,259,404
Granted Patent B2
US 9,259,404 · App. 14/389,082 · Granted Feb 16, 2016

4-oxo-2-pentenoic acid and brain health

Inventors: Francia Jacqueline Arce Vera (Lausanne, CH); Bertrand Bourqui (Murist, CH); Timo Buetler (Zurich, CH); Stephane Duboux (St-Prex, CH); Jane Durga (Miex, CH); Francis Foata (Lausanne, CH); Philippe Alexandre Guy (Lucens, CH); Nicolas Page (Lausanne, CH); Serge Andre Dominique Rezzi (Semsales, CH); Pierre Magistretti (Epalinges, CH); Evelyne Ruchti (Lausanne, CH); Sylvain Lengacher (Lausanne, CH); Igor Allaman (Lausanne, CH)
Assignee: Nestec S.A.
A61K31/19A23L1/30A61K35/74C12N1/20C12P7/40A23V2002/00A23Y2300/29
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Quick Facts
Patent No.
US 9,259,404
App. No.
14/389,082
Granted
Feb 16, 2016
Kind
B2
Abstract

The present invention relates generally to compositions with a health benefit. In particular, the invention relates to the field of brain health, for example brain protection, maintenance of cognitive function, prevention of cognitive decline and prevention of cognitive disorders. A subject matter of the invention is a composition comprising 4-oxo-2-pentenoic acid for use in the treatment or prevention of cognitive decline.

Claims (12)

1. A method for the treatment or prevention of cognitive decline comprising administering a non-pharmaceutical composition comprising 4-oxo-2-pentenoic acid to an individual having or at risk of cognitive decline.

2. Method in accordance with claim 1 , for use in the treatment or prevention of memory loss.

3. Method in accordance with claim 1 for the treatment or prevention of loss of learning capability.

4. Method in accordance with claim 1 , wherein the 4-oxo-2-pentenoic acid is obtained from natural sources.

5. Method in accordance with claim 1 , wherein the 4-oxo-2-pentenoic acid is obtainable from Bifidobacterium breve CNCM I-3865 or Bifidobacterium breve ATCC 15700.

6. Method in accordance with claim 5 , wherein the Bifidobacterium breve CNCM I-3865 or Bifidobacterium breve ATCC 15700 was heat treated at about 60-180° C.

7. Method in accordance with claim 1 , wherein the composition comprises 4-oxo-2-pentenoic acid in an amount of at least 1 mg per kg of the composition.

8. Method in accordance with claim 1 , wherein the composition is administered in a daily dose corresponding to between 2 μg and 20 mg of 4-oxo-2-pentenoic acid per kg of body weight.

9. Method in accordance with claim 1 , wherein the composition is administered orally or enterally.

10. Method in accordance with claim 1 , wherein the composition is administered to humans or pets.

11. Method in accordance with claim 1 , wherein the composition is administered to adults.

12. Method in accordance with claim 1 , wherein the composition is selected from the group consisting of a food composition, a food additive, a nutraceutical, a drink, a nutritional formulation, a tube feeding formulation, a powdered composition to be reconstituted in milk or water, and a pet food composition.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 27, 2022
From: SOCIÉTÉ DES PRODUITS NESTLÉ SA
To: GLIAPHARM SA
Reel/Frame 062208/0283 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0001 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 16062921 PREVIOUSLY RECORDED ON REEL 049391 FRAME 0756. ASSIGNOR(S) HEREBY CONFIRMS THE PATENT NUMBER SHOULD HAVE BEEN 16062912. Recorded Jul 3, 2020
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 054082/0165 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ENGLISH TRANSLATION TO SHOW THE FULL AND CORRECT NEW NAME IN SECTION 51. PREVIOUSLY RECORDED AT REEL: 049391 FRAME: 0756. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER. Recorded Jun 13, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049853/0398 →
MERGER Recorded Jun 6, 2019
From: NESTEC S.A.
To: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
Reel/Frame 049391/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2015
From: PAGE, NICOLAS; DURGA, JANE; FOATA, FRANCIS; BUETLER, TIMO; GUY, PHILIPPE ALEXANDRE; REZZI, SERGE ANDRE DOMINIQUE; ARCE VERA, FRANCIA JACQUELINE; BOURQUI, BERTRAND; DUBOUX, STEPHANE; ALLAMAN, IGOR; LENGACHER, SYLVAIN; RUCHTI, EVELYNE; MAGISTRETTI, PIERRE
To: NESTEC S.A.
Reel/Frame 037279/0651 →
Priority Claims (1)
EP 12162358 · Mar 30, 2012 · regional
Continuity (1)
Related Publication 20150105464A1 · Apr 16, 2015