Nanoclusters compositions and methods
Compositions, methods of making, and methods of using nanoclusters in which the nanoclusters comprise a plurality of nanoparticles having a core of nanoparticles arranged such that the surfaces of the nanoparticles contact adjacent nanoparticles, the nanoparticles comprise an active ingredient, and the nanocluster has a mass median aerodynamic diameter of from about 0.25 μm to about 20 μm.
1. A method comprising administering to a subject a composition, the composition comprising nanocluster comprised of a core of nanoparticles arranged such that the surface of the nanoparticles contact one another, the nanoparticles comprise an active ingredient, wherein the nanocluster has a mass median aerodynamic diameter of from about 0.25 μm to about 20 μm.
2. The method of claim 1 , further comprising determining if a subject is in need of treatment.
3. The method of claim 1 , wherein the active ingredient is an anti-inflammatory compound, a bronchodilator, an antimicrobial, a vaccine, an analgesic, an anxiolytic, a hypnotic, a vasodilator, a cytotoxic agent, an opiod, an anti-cancer agent, DNA, RNA, budesonide, vancomycin, moxifloxacin, mometazone, epinephrine, 13 C labeled urea, atropine, or diatrizoic acid.
4. The method of claim 3 wherein the subject has a medical condition that is treated with at least one of the active ingredients selected from the group consisting of an anti-inflammatory compound, a bronchodilator, an antimicrobial, a vaccine, an analgesic, an anxiolytic, a hypnotic, a vasodilator, a cytotoxic agent, an opiod, an anti-cancer agent, DNA, RNA, budesonide, vancomycin, moxifloxacin, mometazone, epinephrine, 13 C labeled urea, atropine, or diatrizoic acid.
5. The method of claim 1 , wherein the composition is formulated as a dry powder, a suspension, an aerosol, a spray, a tablet, or a liquid.
6. The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
7. The method of claim 1 , wherein the nanoparticles consists essentially of the active ingredient.
8. The method of claim 1 , wherein the step of administering the composition is performed by topical administration.
9. The method of claim 1 , wherein the step of administering the composition is performed by nasal administration.
10. The method of claim 1 , wherein the step of administering the composition is performed through medical tubing.
11. The method of claim 1 , wherein the step of administering the composition is performed by oral administration.
12. The method of claim 1 , wherein the step of administering the composition is performed by injection.
13. The method of claim 1 , wherein the step of administering the composition is performed by nebulization.
14. The method of claim 1 , wherein the step of administering the composition is performed by a dry powder inhaler.
15. The method of claim 1 , wherein the step of administering the composition is performed by a pressurized metered dose inhaler.
16. The method of claim 12 , wherein the injection is intravitreal or intraocular.
17. The method of claim 1 , wherein the composition is formulated as eye drops.
18. The method of claim 17 , wherein the step of administering the composition is performed by applying the eye drops to the subject's eyes.
19. The method of claim 17 , wherein the active ingredient is an antibiotic.
20. The method of claim 17 , wherein the active ingredient is a non-steroidal anti-inflammatory drug.