Granted Patent
B2
US 9,522,950 · App. 14/705,362 · Granted Dec 20, 2016
Oxidant resistant apolipoprotein A-1 and mimetic peptides
Assignee:
The Cleveland Clinic Foundation
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Abstract
A purified polypeptide includes an ApoA1 mimetic or fragment thereof that are resistant to oxidation.
Claims (3)
1. A method for treating a cardiovascular disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a human proapolipoprotein, comprising the amino acid sequence of SEQ ID NO. 1, in which each X amino acid in the amino acid sequence of SEQ ID NO: 1 is a phenylalanine amino acid.
2. The method of claim 1 , wherein the proapolipoprotein is a purified apolipoprotein.
3. The method of claim 2 , wherein proapolipoprotein is a recombinant proapolipoprotein produced in bacteria, yeast, plant, insect, avian, or mammalian cells.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 17, 2016
From: SMITH, JONATHAN D.; HAZEN, STANLEY L.
To: THE CLEVELAND CLINIC FOUNDATION
Reel/Frame 038621/0280 →
Continuity (5)
Provisional Application
60981887
· Oct 23, 2007