Sustained release of nutrients in vivo
Nutritional compositions delivered in vivo in a time controlled manner sustainable over long periods of time, provide enhancing athletic performance, increased hand/eye coordination and concentration on the task at hand.
1. A hydrogel particle, wherein the particle has a diameter less than or equal to about 1000 micrometers, and wherein the particle comprises:
(a) at least one biologically active agent;
(b) one or more compounds for time controlled and sustained release of the at least one biologically active agent of (a) in vivo, wherein the one or more compounds for time controlled and sustained release are non-toxic and are crosslinked;
(c) at least one compound that is pH-sensitive, wherein the at least one pH-sensitive compound does not swell at pH 1-3; and
(d) at least one compound that is temperature-sensitive, wherein the at least one temperature-sensitive compound has a lower critical solution temperature in aqueous solution.
2. The hydro gel particle of claim 1 , wherein the at least one biologically active agent is a nutritional supplement selected from the group consisting of: minerals, proteins, carbohydrates, amino acids, lipids, electrolytes and vitamins.
3. The hydrogel particle of claim 1 , wherein the one or more compounds for the time controlled and sustained release of the at least one biologically active agent are selected from the group consisting of: biodegradable polymers, bioadhesives, and binders.
4. The hydrogel particle of claim 3 , wherein the biodegradable polymers and binders are selected from the group consisting of: poly(lactide)s, poly(glycolide)s, poly(lactide-co-glycolide)s, poly(lactic acid)s, poly(glycolic acid)s, poly(lactic acid-co-glycolic acid)s, polycaprolactone, polycarbonates, polyesteramides, polyanhydrides, poly(amino acids), polyorthoesters, polyacetyls, polycyanoacrylates, polyetheresters, poly(dioxanone)s, poly(alkylene alkylate)s, copolymers of polyethylene glycol and polyorthoester, biodegradable polyurethanes, polysaccharides, and polysaccharide copolymers with polyethers.
5. A beverage, a gum, a food snack or a powder comprising a plurality of hydrogel particles of claim 1 .
6. The hydrogel particle of claim 1 , wherein the hydrogel particle comprises at least one modified polysaccharide.
7. The hydrogel particle of claim 6 wherein the polysaccharide modification is selected from the group consisting of: carboxylic acid, acryloyl or methacryloyl, hydroxyalkyl, ester, grafted fatty acid moieties, oligo(alkylene oxide) grafts, functionalized hydrophobes, grafted amphiphiles, and side chain derivatizations to introduce aldehydic or carboxylic groups.
8. The hydrogel particle of claim 1 , wherein the hydrogel particle increases the retention time of the at least one biologically active agent in the small intestine because of the mucoadhesive nature of the hydrogel particle.
9. The hydrogel particle of claim 1 , wherein the one or more compounds for time controlled and sustained release are crosslinked using inorganic salts, or free radical initiators, or redox systems involving ascorbic acid, or a naturally occurring crosslinker.
10. The hydrogel particle of claim 9 , wherein the one or more compounds for time controlled and sustained release are ionically crosslinked.
11. The hydrogel particle of claim 1 , wherein the one or more compounds for time controlled and sustained release are covalently crosslinked.
12. The hydrogel particle of claim 1 , further comprising a surfactant.
13. The hydrogel particle of claim 1 , wherein the one or more compounds for time controlled and sustained release comprise a polysaccharide, wherein the polysaccharide is a naturally occurring anionic polymer.
14. The hydrogel particle of claim 1 , wherein the at least one pH-sensitive compound of (c) is a carboxy-containing polysaccharide.
15. The hydrogel particle of claim 14 , wherein the carboxy-containing polysaccharide is alginate or carboxymethyl cellulose.
16. The hydrogel particle of claim 1 , wherein the at least one temperature-sensitive compound of (d) is a hydrophobically modified polysaccharide.
17. The hydrogel particle of claim 16 , wherein the hydrophobically modified polysaccharide is selected from the group consisting of: hydroxypropyl cellulose, hydroxypropylmethyl cellulose, and hydroxyethyl cellulose.
18. The hydrogel particle of claim 1 , wherein the at least one pH-sensitive compound of (c) is a carboxy-containing polysaccharide and the at least one temperature-sensitive compound of (d) is a hydrophobically modified polysaccharide.
19. The hydrogel particle of claim 1 , wherein the particle swells in the pH environment of the small intestine.