Polyvalent chimeric OSPC vaccinogen and diagnostic antigen
A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammaliran Borrelia infections.
1. A chimeric recombinant protein comprising an amino acid sequence having at least 95% identity to SEQ ID NO: 251.
2. The chimeric recombinant protein of claim 1 , wherein the amino acid sequence has at least 96% identity to SEQ ID NO: 251.
3. The chimeric recombinant protein of claim 1 , wherein the amino acid sequence has at least 97% identity to SEQ ID NO: 251.
4. The chimeric recombinant protein of claim 1 , wherein the amino acid sequence has at least 98% identity to SEQ ID NO: 251.
5. The chimeric recombinant protein of claim 1 , wherein the amino acid sequence has at least 99% identity to SEQ ID NO: 251.
6. The chimeric recombinant protein of claim 1 , wherein the amino acid sequence is SEQ ID NO: 251.
7. The chimeric recombinant protein of claim 1 , wherein an amino acid sequence of the chimeric recombinant protein is SEQ ID NO: 251.