Secondary structure stabilized NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain.
1. A method of modulating an NMDA receptor, wherein the method comprises administering the compound represented by:
wherein
R 4 is H;
R 1 is benzyl;
R 5 is
R 6 is
R 2 is H or CH 3 ;
R 3 is H or CH 3 ;
and stereoisomers, N-oxides or pharmaceutically acceptable salts thereof.
2. The method of claim 1 , wherein R 2 and R 3 are CH 3 .
3. The method of claim 1 , wherein R 2 is CH 3 and R 3 is H.
4. The method of claim 1 , wherein the compound is: