IP Library Granted Patent US 9,644,169
Granted Patent B2
US 9,644,169 · App. 15/180,431 · Granted May 9, 2017

Bioeffective krill oil compositions

Inventors: Inge Bruheim (Volda, NO); Snorre Tilseth (Bergen, NO); Daniele Mancinelli (Orsta, NO)
Assignee: AKER BIOMARINE ANTARCTIC AS
C11B3/006A61K9/0053A61K9/48A61K9/4825A61K9/4858A61K31/122A61K31/20A61K31/202A61K31/23A61K31/235A61K31/683A61K31/685A61K35/612A61K45/06
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Quick Facts
Patent No.
US 9,644,169
App. No.
15/180,431
Granted
May 9, 2017
Kind
B2
Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

Claims (26)

1. A method of production of krill oil comprising:

a) providing krill;

b) treating said krill to denature lipases and phospholipases in said krill to provide a denatured krill product;

c) storing said denatured krill product for a storage period of from 1 to 24 months;

d) after said storage period, extracting oil from said denatured krill product with a polar solvent to provide a krill oil with from about 3% to about 15% ether phospholipids w/w of said krill oil astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

2. The method of claim 1 , wherein said steps a and b are performed on a ship.

3. The method of claim 1 , wherein said treating comprises heating.

4. The method of claim 1 , wherein said denatured krill product is a krill meal.

5. The method of claim 1 , wherein said krill is freshly harvested.

6. The method of claim 1 , further comprising encapsulating said krill oil.

7. The method of claim 1 , wherein said krill is Antarctic krill.

8. The method of claim 7 , wherein said Antarctic krill is Euphausia superba.

9. The method of claim 1 , wherein said krill oil contains astaxanthin esters in an amount of greater than about 200 mg/kg of said krill oil.

10. The method of claim 1 , wherein said krill oil comprises at least 30% total phospholipids w/w of said krill oil.

11. The method of claim 1 , wherein said krill oil comprises at least 30% phosphatidylcholine w/w of said krill oil.

12. A method of production of krill oil comprising:

a) obtaining a denatured krill product produced by treating freshly harvested krill krill to denature lipases and phospholipases in said krill and that has been stored from 1 to 24 months; and

b) extracting oil from said denatured krill product that has been stored from 1 to 24 months with a polar solvent to provide a krill oil with from about 3% to about 15% ether phospholipids w/w of said krill oil astaxanthin esters in amount of greater than about 100 mg/kg of said krill oil.

13. The method of claim 12 , wherein said treating comprises heating.

14. The method of claim 12 , wherein said denatured krill product is a krill meal.

15. The method of claim 12 , wherein said krill is freshly harvested.

16. The method of claim 12 , further comprising encapsulating said krill oil.

17. The method of claim 12 , wherein said krill is Antarctic krill.

18. The method of claim 17 , wherein said Antarctic krill is Euphausia superba.

19. The method of claim 12 , wherein said krill oil contains astaxanthin esters in an amount of greater than about 200 mg/kg of said krill oil.

20. The method of claim 12 , wherein said krill oil comprises at least 30% total phospholipids w/w of said krill oil.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 12, 2016
From: AKER BIOMARINE AS
To: AKER BIOMARINE ANTARCTIC AS
Reel/Frame 039421/0228 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 10, 2016
From: BRUHEIM, INGE; TILSETH, SNORRE; MANCINELLI, DANIELE
To: AKER BIOMARINE AS
Reel/Frame 039396/0844 →
Continuity (7)
Continuation 14020162 · Sep 6, 2013
Continuation 12057775 · Mar 28, 2008
Provisional Application 60920483 · Mar 28, 2007
Provisional Application 60975058 · Sep 25, 2007
Provisional Application 60983446 · Oct 29, 2007
Provisional Application 61024072 · Jan 28, 2008
Related Publication 20160281026A1 · Sep 29, 2016