Method of treating atopic dermatitis with IL-31 monoclonal antibodies
The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.
1. A method of treating atopic dermatitis in a mammal comprising administering to the mammal a therapeutically effective amount of a monoclonal antibody that specifically binds to a polypeptide consisting of amino acid residues 27 to 164 of SEQ ID NO:2, wherein the monoclonal antibody binds to the same epitope as the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815, and wherein after administration the scratching associated with the atopic dermatitis is reduced.
2. The method of claim 1 , wherein the antibody is a human antibody.
3. The method of claim 1 , wherein the antibody is a humanized antibody.
4. The method of claim 1 , wherein the antibody comprises a human IgG heavy chain immunoglobulin constant domain.
5. The method of claim 1 , wherein the antibody is the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815.
6. The method of claim 5 , wherein the antibody is a humanized antibody.
7. The method of claim 6 , wherein the humanized antibody comprises a human IgG heavy chain immunoglobulin constant domain.
8. A method of treating atopic dermatitis in a mammal comprising administering to the mammal a therapeutically effective amount of a pharmaceutical composition comprising a monoclonal antibody that specifically binds to a polypeptide consisting of amino acid residues 27 to 164 of SEQ ID NO:2 and a pharmaceutically acceptable carrier, wherein the monoclonal antibody binds to the same epitope as the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815, and wherein after administration the scratching associated with the atopic dermatitis is reduced.
9. The method of claim 8 , wherein the antibody is a human antibody.
10. The method of claim 8 , wherein the antibody is a humanized antibody.
11. The method of claim 8 , wherein the antibody comprises a human IgG heavy chain immunoglobulin constant domain.
12. The method of claim 8 , wherein the antibody is the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-6815.
13. The method of claim 12 , wherein the antibody is a humanized antibody.
14. The method of claim 13 , wherein the humanized antibody comprises a human IgG heavy chain immunoglobulin constant domain.