IP Library › Granted Patent US 9,850,476
Granted Patent B2
US 9,850,476 · App. 15/082,635 · Granted Dec 26, 2017

Degradable clostridial toxins

Inventors: Lance E. Steward (Irvine, CA); Sanjiv Ghanshani (Irvine, CA); Ester Fernandez-Salas (Ann Arbor, MI); Marcella A. Gilmore (Santa Ana, CA); Joseph Francis (Aliso Viejo, CA); Kei Roger Aoki (Coto de Caza, CA)
Assignee: Allergan, Inc.
C12N9/52A61K38/4893C07K14/33C12Y304/24069
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Quick Facts
Patent No.
US 9,850,476
App. No.
15/082,635
Granted
Dec 26, 2017
Kind
B2
Abstract

The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

Claims (1)

1. A non-naturally occurring Clostridial toxin comprising SEQ ID NO: 537; wherein the non-naturally occurring Clostridial toxin comprises an inactivation cleavage site not present in a naturally occurring Clostridial toxin.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2016
From: STEWARD, LANCE E.; GHANSHANI, SANJIV; FERNANDEZ-SALAS, ESTER; GILMORE, MARCELLA A.; FRANCIS, JOSEPH; AOKI, KEI ROGER
To: ALLERGAN, INC.
Reel/Frame 038115/0334 →
Continuity (5)
Continuation 14088022 · Nov 22, 2013
Division 13846364 · Mar 18, 2013
Division 13112844 · May 20, 2011
Provisional Application 61346578 · May 20, 2010
Related Publication 20160201046A1 · Jul 14, 2016