IP Library › Granted Patent US 9,914,751
Granted Patent B2
US 9,914,751 · App. 14/806,924 · Granted Mar 13, 2018

Natural IGM antibodies and inhibitors thereof

Inventors: Michael C. Carroll (Wellesley, MA); Francis D. Moore, Jr. (Medfield, MA); Herbert B. Hechtman (Chestnut Hill, MA)
Assignees: Children's Medical Center Corporation; President and Fellows of Harvard College; The Brigham and Women's Hospital, Inc.
C07K7/08C07K16/00C07K16/18C07K16/28A61K38/00A61K39/00A61K2039/505A61K2039/57C07K2317/34C07K2317/52
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Quick Facts
Patent No.
US 9,914,751
App. No.
14/806,924
Granted
Mar 13, 2018
Kind
B2
Abstract

The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.

Claims (10)

1. A composition comprising a peptide having a sequence comprising the amino acid sequence of SEQ ID NO: 30.

2. The composition of claim 1 , wherein the peptide has a sequence consisting of the amino acid sequence of SEQ ID NO: 30.

3. The composition of claim 1 , wherein the peptide is pegylated.

4. The composition of claim 1 , wherein the peptide is labeled with a detectable label.

5. A method of treating a subject having an inflammatory disease or inflammatory disorder comprising administering to the subject a composition comprising a therapeutically effective dose of a peptide having a sequence comprising the amino acid sequence of SEQ ID NO: 30.

6. The method of claim 5 , wherein the inflammatory disease or inflammatory disorder is reperfusion injury.

7. The method of claim 5 , wherein the subject is a mammal.

8. The method of claim 5 , wherein the mammal is a human.

9. The method of claim 5 , wherein the inflammatory disease or inflammatory disorder is a burn injury.

10. The method of claim 5 , wherein the peptide has a sequence consisting of the amino acid sequence of SEQ ID NO: 30.

Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S NAME (ID503459628) PREVIOUSLY RECORDED ON REEL 036458 FRAME 080. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNEE'S NAME SHOULD BE THE CHILDREN'S MEDICAL CENTER CORPORATION. Recorded Sep 3, 2015
From: IMMUNE DISEASE INSTITUTE, INC.
To: THE CHILDREN'S MEDICAL CENTER CORPORATION
Reel/Frame 036538/0492 →
MERGER Recorded Aug 31, 2015
From: IMMUNE DISEASE INSTITUTE, INC.
To: THE CHILDREN'S HOSPITAL CORPORATION
Reel/Frame 036458/0080 →
CHANGE OF NAME Recorded Aug 25, 2015
From: THE CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC.
To: IMMUNE DISEASE INSTITUTE, INC.
Reel/Frame 036446/0550 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2015
From: CARROLL, MICHAEL C.
To: CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC.
Reel/Frame 036391/0485 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2015
From: MOORE, FRANCIS D., JR.
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 036391/0528 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2015
From: HECHTMAN, HERBERT B.
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 036391/0599 →
Continuity (5)
Continuation 12259767 · Oct 28, 2008
Continuation 11069834 · Mar 1, 2005
Provisional Application 60588648 · Jul 16, 2004
Provisional Application 60588648 · Jul 16, 2004
Related Publication 20160280740A1 · Sep 29, 2016