4′-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
1. A compound of formula:
or a pharmaceutically acceptable salt, solvate, prodrug, clathrate, or stereoisomer thereof, wherein:
Y is C═O or CH 2 ; and
R 1 is alkenyl, alkynyl, bicyclic aryl, cycloalkyl, cycloalkylalkyl, arylaminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonyl, or cycloalkylcarbonyl; and wherein R 1 is optionally substituted with one or more groups selected from alkoxy, halo, alkyl, carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, amine, nitrile, haloalkyl, hydroxy, and alkyl sulfonyl.
2. The compound of claim 1 , selected from:
3. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.
4. A compound having the formula:
or a pharmaceutically acceptable salt, solvate, prodrug, clathrate, or stereoisomer thereof.
5. A pharmaceutical composition comprising a compound of claim 4 , or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.