Melampomagnolide B derivatives
The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, thiocarbamates, ester and amide derivatives of MMB. These derivatives are useful for treating cancer in humans.
1. A method for inhibiting growth of a cancer cell, the method comprising contacting the cancer cell with an amount of a compound comprising Formula (I), or a salt thereof, effective to inhibit growth of the cancer cell, the compound comprising Formula (I):
wherein:
R is selected from the group consisting of
wherein:
R 1 is selected from the group consisting of substituted indoles, substituted heterocyclic aromatic, and substituted aromatic derivatives;
R 2 is selected from the group consisting of substituted indoles; and
R 3 is selected from the group consisting of substituted amines;
wherein the cancer cell is an acute myelogenous leukemia (AML) cancer cell or a solid tumor cell; and
wherein the solid tumor cell is selected from the group consisting of non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer.
2. The method of claim 1 , wherein Formula (I) comprises:
wherein:
X is selected from the group consisting of S, O, NH, NR 10 ;
R 9 is selected from the group consisting of OMe, Cl, Br and F; and
R 10 is selected from the group consisting of H, CH 3 , benzyl, substituted benzyl, benzoyl, substituted benzoyl, and benzylsulfonyl and substituted benzylsulfonyl.
3. The method of claim 1 , wherein Formula (I) comprises:
Wherein:
R 11 is selected from the group consisting of H, CH 3 , benzyl, substituted benzyl, benzoyl, substituted benzoyl, and benzylsulfonyl and substituted benzylsulfonyl; and
R 12 and R 13 are independently selected from the group consisting of H, F, Cl, Br, OCH 3 , CN, CH 3 , NO 2 and COOCH 3 .
4. The method of claim 1 , wherein Formula (I) comprises:
wherein:
R 14 is selected from the group consisting of 2-thiophenyl, 3-thiophenyl, 2-pyrazine, 3-pyrazine, 2-amino nicotinic acid, indole-3-acetic acid, indole-3-acrylic acid.
5. The method of claim 1 , wherein Formula (I) comprises:
wherein:
R 15 is selected from the group consisting of:
6. The method of claim 1 , wherein Formula (I) comprises:
wherein:
R 1 is selected from the group consisting of substituted indoles, substituted heterocyclic aromatic, aromatic and aliphatic derivatives.
7. The method of claim 1 , wherein the cancer cell is in vivo or in vitro.