IP Library › Granted Patent US 9,987,331
Granted Patent B2
US 9,987,331 · App. 15/436,426 · Granted Jun 5, 2018

Treating cardiovascular or renal diseases

Inventors: Yasuhiro Ikeda (Rochester, MN); Stephen James Russell (Rochester, MN); Alessandro Cataliotti (Rochester, MN); John C. Burnett, Jr. (Rochester, MN); Jason M. Tonne (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
A61K38/2242C12N7/00C12N2750/14143C12N2750/14171
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Quick Facts
Patent No.
US 9,987,331
App. No.
15/436,426
Granted
Jun 5, 2018
Kind
B2
Abstract

This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic polypeptides, nucleic acid molecules encoding natriuretic polypeptides, methods for making AAV9 vectors, and methods for using such vectors or molecules to treat cardiovascular and/or renal diseases are provided.

Claims (8)

1. A method for reducing blood pressure in a mammal having renal disease, wherein said method comprises administering an AAV8 or AAV9 vector to said mammal, wherein said vector comprises a nucleic acid sequence encoding a natriuretic polypeptide.

2. The method of claim 1 , wherein said mammal is a human.

3. The method of claim 1 , wherein said natriuretic polypeptide is a human BNP polypeptide.

4. The method of claim 1 , wherein said natriuretic polypeptide is a CDNP polypeptide.

5. The method of claim 1 , wherein said natriuretic polypeptide is a B-CDNP polypeptide.

6. The method of claim 1 , wherein said natriuretic polypeptide is a C-CDNP polypeptide.

7. The method of claim 1 , wherein said vector is an AAV8 vector.

8. The method of claim 1 , wherein said vector is an AAV9 vector.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2018
From: IKEDA, YASUHIRO; RUSSELL, STEPHEN JAMES; CATALIOTTI, ALESSANDRO; BURNETT, JOHN C., JR.; TONNE, JASON M.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 045651/0201 →
CONFIRMATORY LICENSE Recorded Jun 7, 2017
From: MAYO CLINIC ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042706/0759 →
Continuity (3)
Continuation 14370554
Provisional Application 61584006 · Jan 6, 2012
Related Publication 20170232072A1 · Aug 17, 2017