System and method for diagnosis and treatment
This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy utilizing a GCR antagonist, such as ORG 34517. The rapid, sensitive, and inexpensive test can be used to determine patients who have non-normal cortisol production or disordered circadian rhythms as a method for selecting subjects for GCR antagonist therapy for whom it is likely to have beneficial and/or therapeutic effects, and can also be used to monitor changes in cortisol levels in response to treatment.
1. A method for low toxicity chemo treatment by targeted liver infusion in patients with forms of established cirrhosis that are high risk for emergence of HCC, including those with premalignant lesions diagnosed on biopsy or by radiology, comprising targeted delivery of ORG 34517 to intrahepatic lesions, wherein the targeted delivery of ORG 34517 to intrahepatic lesions treat emergence of hepatocellular carcinoma (HCC).
2. The method of claim 1 , wherein the patient with HCC is not a candidate to undergo surgical intervention.
3. The method of claim 1 , wherein the HCC resides in locations where surgical or ablative interventions are not available.
4. The method of claim 1 , wherein the patient with HCC has cirrhosis that is too advanced to make partial hepatectomy safe.
5. The method of claim 1 , wherein the patient with HCC is too early in their chronic liver disease to qualify for transplantation.
6. The method of claim 1 , wherein the HCC is too advanced for localized treatments.