Oral care composition comprising zinc amino acid halides
Disclosed herein are oral care compositions comprising a zinc amino acid halide. Methods of making and using the compositions are also provided.
1. An oral care composition comprising a zinc amino acid halide complex, wherein the amino acid is lysine, and the complex has the chemical structure [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl − , either in solution of the cation ([Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + ) and the chloride anion, or in solid salt form, optionally in monohydrate or dihydrate form, and wherein the composition is in the form of a toothpaste, powder, cream, strip, or gum.
2. The composition of claim 1 , wherein the zinc amino acid halide is formed from precursors.
3. The composition of claim 2 , wherein the precursors are a zinc ion source, an amino acid source, and a halide source.
4. The composition of claim 3 , wherein the halide source is part of the zinc ion source, the amino acid source, or a halogen acid.
5. The composition of claim 1 wherein the amount of zinc in the composition is 0.05-4% by weight.
6. The composition of claim 1 wherein the zinc is solubilized in the composition, but provides a zinc precipitate upon dilution to 1:16 with saliva and/or rinsing.
7. The composition of claim 1 in the form of a toothpaste.
8. The composition of claim 1 further comprising an effective amount of a fluoride ion source.
9. The composition of claim 1 further comprising an orally acceptable base comprising ingredients selected from one or more of abrasives, buffering agents, humectants, surfactants, thickeners, gum strips or fragments, breath fresheners, flavoring, fragrance, coloring, antibacterial agents, whitening agents, agents that interfere with or prevent bacterial attachment, calcium sources, phosphate sources, orally acceptable potassium salts, anionic polymers, and combinations thereof, wherein the composition is in the form of a toothpaste.
10. The composition of claim 1 wherein the pH of the composition is from pH 6 to pH 8.
11. A method of manufacturing an oral care composition according to claim 1 , comprising the step of adding a zinc amino acid halide to the composition during manufacture.
12. A method of treating or reducing dental enamel erosion cleaning the teeth, reducing bacterially-generated biofilm and plaque, reducing gingivitis, inhibiting tooth decay and formation of cavities, and/or reducing dentinal hypersensitivity comprising applying a composition according to claim 1 to the teeth.