Granted Patent
B2
US 12,653,773 · App. 18/418,609 · Granted Jun 16, 2026
Oral care compositions comprising hops beta acid and amino acid
Inventors:
Yunming Shi (Beijing, CN); Samuel James St. John (Cincinnati, OH); Ross Strand (Singapore, SG)
Assignee:
The Procter & Gamble Company
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Abstract
Oral care compositions with an anticaries or anticavity effect. Oral care compositions that have one or more hops beta acids, such as from an extract from a species in the Humulus family, and one or more amino acids. Oral care compositions having one or more amino acids and an extract from Humulus lupulus . Methods of use of the disclosed compositions to disrupt biofilm in the oral cavity of a patient in need of treatment.
Claims (26)
1 . A dentifrice composition comprising:
(a) about 0.01% to about 10%, by weight of the composition, of hops beta acid, wherein the hops beta acid is free of hydrogenated hops beta acid;
(b) about 0.01% to about 10%, by weight of the composition, of glycine;
(c) a tin ion source; and
(d) 10% to 50% of an abrasive comprising calcium,
wherein the dentifrice composition has an LPS neutralization of at least about 60%.
2 . The dentifrice composition of claim 1 , further comprising from about 0.01% to about 10%, by weight of the dentifrice composition, of a fluoride ion source.
3 . The dentifrice composition of claim 2 , wherein the fluoride ion source comprises sodium fluoride, stannous fluoride, amine fluoride, sodium monofluorophosphate, or combinations thereof.
4 . The dentifrice composition of claim 1 , wherein the dentifrice composition is essentially free of fluoride.
5 . The dentifrice composition of claim 1 , wherein the abrasive comprises calcium carbonate.
6 . The dentifrice composition of claim 1 , wherein the hops beta acid comprises lupulone, colupulone, adlupulone, or combinations thereof.
7 . The dentifrice composition of claim 1 , further comprising from about 0.01% to about 10%, by weight of the composition, of an antibacterial agent.
8 . The dentifrice composition of claim 7 , wherein the antibacterial agent comprises a metal ion source.
9 . The dentifrice composition of claim 8 , wherein the metal ion source comprises zinc.
10 . The dentifrice composition of claim 1 , wherein the tin ion source comprises stannous fluoride, stannous chloride, or a combination thereof.
11 . The dentifrice composition of claim 1 , further comprising an amino acid selected from a basic amino acid, an acidic amino acid, a neutral amino acid, and combinations thereof.
12 . The dentifrice compositions of claim 11 , wherein the amino acid comprises alanine, valine, isoleucine, tryptophan, phenylalanine, proline, methionine, leucine, serine, threonine, tyrosine, asparagine, glutamine, cysteine, citrulline, aspartic acid, glutamic acid, lysine, arginine, histidine, or a combination thereof.
13 . The dentifrice composition of claim 1 , wherein the hops beta acid comprises an extract of Humulus lupulus , the extract comprising less than 1%, by weight of the extract, of hops alpha acid.
14 . The dentifrice composition of claim 13 , wherein the extract comprises less than 5%, by weight of the extract, of hops oils.
15 . The oral care composition of claim 1 , wherein a reduction of biofilm thickness is at least 45% relative to an equivalent oral care composition without glycine.
16 . A method of disrupting a dental biofilm in an oral cavity of a patient comprising:
applying the dentifrice composition of claim 1 to the dental biofilm.
17 . The method of claim 16 , wherein the dental biofilm has a thickness reduction of at least 60% after application of the dentifrice composition.
18 . The method of claim 16 , wherein the dental biofilm has a thickness reduction of at least 75% after application of the dentifrice composition.
19 . The dentifrice composition of claim 5 , wherein the abrasive is present at about 20% to about 50%.
20 . The dentifrice composition of claim 19 , wherein the abrasive is free of silica.
Priority Claims (1)
WO PCT/CN2019/109392
· Sep 30, 2019
· international
Continuity (3)
Continuation
PCTCN2020119144
· Sep 30, 2020
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