Peptide having antimicrobial activity against pathogens and antimicrobial peptide composition comprising the same
View Patent ↗An antimicrobial peptide and an antimicrobial peptide composition comprising the same are provided. The antimicrobial peptide and the antimicrobial peptide composition have remarkably high antibacterial activity against gram-positive (+) and gram-negative (−) bacteria, compared to wild-type LPcin-I having an antimicrobial ability, which consists of a sequence of 23 amino acids. Also, the antimicrobial peptide can be useful in being easily synthesized and saving production costs since the antimicrobial peptide has a smaller number of amino acids, compared to the wild-type LPcin-I.
1. A peptide represented by the following sequence [General Formula I] having antimicrobial activity against pathogens:
[General Formula I]
[(N-terminus)-N K V K E W X 1 K X 2 L K X 3 X 4 F
X 5 -(C-terminus)]
wherein X 1 is I or W, X 2 is Y when X 1 is I, and X 2 is W when X 1 is W;
X 3 is S or K;
X 4 is L or K; and
X 5 is S or K,
wherein the sequence of the peptide is not NKVKEWIKYLKSLFS (SEQ ID NO: 1).
2. The peptide of claim 1 , wherein the peptide is a peptide from which X 3 X 4 F X 5 or F X 5 in General Formula I is deleted.
3. The peptide of claim 1 , wherein the peptide consists of any one amino acid sequence selected from the group consisting of SEQ ID NOs: 2 to 10.
4. An antimicrobial peptide composition comprising the antimicrobial peptide of any one of claims 1 to 3 as an active ingredient.
5. The antimicrobial peptide composition of claim 4 , wherein the antimicrobial activity is antimicrobial activity against one or more bacteria selected from the group consisting of Staphylococcus aureus, Salmonella spp., Listeria innocua, Pseudomonas aeruginosa , and Escherichia coli.
6. A peptide represented by the following sequence [General Formula I] having antimicrobial activity against pathogens:
[General Formula I]
[(N-terminus)-
N K V K E W X 1 K X 2 L K X 3 X 4 F X 5 -(C-terminus)]
wherein X 1 is I or W, X 2 is Y when X 1 is I, and X 2 is W when X 1 is W;
X 3 is S or K;
X 4 is L or K; and
X 5 is S or K, and
wherein the peptide is a peptide from which X 3 X 4 F X 5 or F X 5 in General Formula I is deleted.