IP Library › Granted Patent US 12,319,752
Granted Patent B2
US 12,319,752 · App. 17/525,354 · Granted Jun 3, 2025

Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Inventors: Run Chang (Brighton, MA); Keerthana Subramanian (Boston, MA); Mian Wang (Malden, MA); Thomas J. Webster (Barrington, RI)
Assignee: Northeastern University
C07K7/08A61P31/04C07H5/06C07H5/10
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Quick Facts
Patent No.
US 12,319,752
App. No.
17/525,354
Granted
Jun 3, 2025
Kind
B2
Abstract

Disclosed are peptides comprising an amphiphilic backbone and a cationic heparin-binding motif peptide. The peptides can be used in methods of antimicrobial treatment.

Claims (26)

1. A method of preventing or suppressing growth of a bacterium on a surface, comprising:

applying to the surface a plurality of polypeptides represented by:

R 1 -y 1 -y 2

wherein

R 1 -y 1 is an amphiphilic backbone;

y 2 is a cationic heparin-binding Cardin motif peptide;

R 1 is an alkyl group or an alkenyl group; and

y 1 has the sequence V 4 K 4 (SEQ ID NO: 1) or V 4 K 4 G (SEQ ID NO: 4)

thereby preventing or suppressing growth of the bacterium on the surface.

2. The method of claim 1 , wherein R 1 is selected from the group consisting of C 12 , C 14 , C 16 , C16:1, C 18 , C18:1, C18:2, C18:3, C 20 , C20:1, C20:4, C20:5, C 22 , C22:1, and C22:6.

3. The method of claim 1 , wherein y 2 has the following sequence (SEQ ID NO: 5):

-(WZZWZW) m

wherein

W is A or G;

Z is K or R; and

m is 2, 3, 4, 5, 6, 7, 8, 9, or 10.

4. The method of claim 3 , wherein W is A.

5. The method of claim 3 , wherein Z is K.

6. The method of claim 3 , wherein m is 2.

7. The method of claim 3 , wherein y 2 has the sequence -(AKKARA) m (SEQ ID NO: 6).

8. The method of claim 1 , wherein the bacterium on the surface is a Gram-negative bacterium.

9. The method of claim 8 , wherein the Gram-negative bacterium on the surface is Gram-negative Escherichia coli.

10. The method of claim 8 , wherein the Gram-negative bacterium on the surface is Gram-negative multidrug-resistant Escherichia coli.

11. The method of claim 1 , wherein the bacterium on the surface is a Gram-positive bacterium.

12. The method of claim 11 , wherein the Gram-positive bacterium on the surface is a Gram-positive Staphylococcus aureus.

13. The method of claim 11 , wherein the Gram-positive bacterium on the surface is a Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA).

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 10, 2022
From: CHANG, RUN; SUBRAMANIAN, KEERTHANA; WANG, MIAN; WEBSTER, THOMAS
To: NORTHEASTERN UNIVERSITY
Reel/Frame 060770/0161 →
Continuity (3)
Continuation 15832194 · Dec 5, 2017
Provisional Application 62430906 · Dec 6, 2016
Related Publication 20220227810A1 · Jul 21, 2022
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