IP Library › Granted Patent US 10,285,938
Granted Patent B2
US 10,285,938 · App. 15/632,350 · Granted May 14, 2019

Composition for the treatment of burns, diabetic wounds, other types of wounds and subsequently greatly reduced scarring

Inventors: Ram Isanaka (Warren, NJ); Jesse Jaynes (Auburn, AL)
Assignee: ISSAR Pharmaceutical
A61K9/06A61K9/0014A61K38/00A61K38/08A61K47/06A61K47/10A61K47/12A61K47/14A61K47/183A61K47/24A61K47/02
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Quick Facts
Patent No.
US 10,285,938
App. No.
15/632,350
Granted
May 14, 2019
Kind
B2
Abstract

Antimicrobial peptides represent a relatively new discovery in the immune system pathway. Recent designs of synthetically engineered antimicrobial peptides have demonstrated increased potency and efficacy/tolerability, enhanced specificity, and reduced toxicity in comparison. One such peptide, XYLENTRA®, has shown/demonstrated significant promise from significant in vitro studies against a large + pathogens. Additionally, extensive animal studies have shown that the XYLENTRA® is an antimicrobial peptide against a large number of pathogens. The XYLENTRA® peptide is also solute resistant. The peptide XYLENTRA® has shown/demonstrated significant antibacterial activity on test organisms Staphylococcus aureus MTCC 96 and Pseudomonas aeruginosa . MTCC741. A substantial decrease in the microbial population level was observed in animals treated with peptide using the protocol described in detail in the application.

Claims (8)

1. A method of treating a wound, which comprises:

administering to the wound a therapeutically effective dose of a composition comprising an antimicrobial peptide,

wherein the antimicrobial peptide comprises SEQ ID NO:1,

thereby yielding significant reduction in scarring caused from wounds.

2. The method of claim 1 , wherein the wound is a burn.

3. The method of claim 1 , wherein the wound is a diabetic wound.

4. The method of claim 1 , wherein the antimicrobial peptide exhibits antimicrobial activity on Staphylococcus aureus and Pseudomonas aeruginosa.

5. The method of claim 1 , wherein the composition is in the form of a cream.

Continuity (2)
Division 14756169 · Aug 11, 2015
Related Publication 20170290770A1 · Oct 12, 2017
Cited By (2)
US 12,319,752 US 12,564,617