Oral compositions containing zinc, stannous and fluoride ion sources

1. An oral care composition comprising in a single phase:

(a) an orally acceptable vehicle;

(b) a source of fluoride ions;

(c) a source of stannous ions;

(d) an insoluble source of zinc ions;

(e) a buffering system comprising citric acid wherein the amount of citric acid is at least 1% by weight of the composition, and

wherein the composition has a total water content of less than 15% by weight, based on the weight of the composition.

2. The composition of claim 1 wherein the amount of citric acid is 1-3 wt. %, or 1.1-1.5 wt. % or 1.8-2.2 wt. %, based on the weight of the composition.

3. The composition of claim 1 wherein the amount of citric acid is 1-3 wt. % based on the weight of the composition.

4. The composition of claim 1 wherein the amount of citric acid is 1.1-1.5 wt. % based on the weight of the composition.

5. The composition of claim 1 wherein the amount of citric acid is 1.8-2.2 wt. % based on the weight of the composition.

6. The composition of claim 1 , wherein the insoluble source of zinc ions comprises zinc oxide, zinc phosphate, zinc pyrophosphate or a mixture thereof.

7. The composition of claim 1 wherein the source of fluoride ions and the source of stannous ions comprises stannous fluoride.

8. The composition of claim 1 comprising at least one polyphosphate salt selected from the group consisting of inorganic polyphosphate salts which have equal to or less than three phosphorous atoms.

9. The composition of claim 8 , wherein the at least one polyphosphate is selected from the group consisting of tetrasodium pyrophosphate, sodium tripolyphosphate, and mixtures thereof; wherein the total polyphosphate comprises from 1 to 10 wt % of the composition.

10. The composition of claim 1 wherein the buffering system comprises a mixture of citric acid and trisodium citrate.

11. The composition of claim 1 comprising polyvinylpyrrolidone, a gum, or a mixture thereof.

12. The composition of claim 1 comprising a modified cellulose such as carboxymethyl cellulose.

13. The composition of claim 1 further comprising at least one humectant selected from the group consisting of glycerin, polyethylene glycol, propylene glycol, and mixtures thereof.

14. The composition of claim 1 wherein the composition is a dentifrice comprising one or more of an abrasive, a surfactant, a foaming agent, a vitamin, a polymer, a whitening agent, an enzyme, a humectant, a thickener, an antimicrobial agent, a preservative, L-arginine, a flavoring, or a coloring agent.

15. The composition of claim 1 comprising:

(a) 1-3 wt. % citric acid;

(b) 0.5-10 wt % Trisodium citrate;

(c) 0.1-5 wt % Zinc oxide;

(d) 0.1-5 wt % Stannous fluoride;

(e) 10-50 wt % Glycerin;

(f) 1-25 wt. % Propylene glycol; optionally comprising one or more of:

(g) 0.1-12 wt % xanthan gum;

(h) 0.25-10 wt % polyvinylpyrrolidone (PVP);

(i) 0.2-1.5% wt. % carboxymethylcellulose (CMC);

(j) 5-60 wt % Silica (total);

(k) 0.1-10 wt % Tetrasodium Pyrophosphate (TSPP);

(l) 0-5 wt % Sodium acid pyrophosphate (SAPP);

(m) 0.1-10 wt % Sodium Tripolyphosphate (STPP);

(n) 0.1-10 wt % Sodium lauryl sulfate (SLS);

(o) 0.1-10 wt % Cocamidopropyl betaine.

16. The oral care composition of claim 15 comprising:

(a) 1.1-1.5 wt. % or 1.8-2.2 wt. % citric acid;

(b) 2-4 wt % Trisodium citrate;

(c) 0.5-2 wt % Zinc oxide;

(d) 0.1-2 wt % Stannous fluoride;

(e) 10-50 wt % Glycerin;

(f) 2-10 wt % Propylene glycol; optionally comprising one or more of:

(g) 0.1-0.5% wt % xanthan gum;

(h) 0.25-10 wt % polyvinylpyrrolidone (PVP);

(i) 0.3-0.9 wt. % carboxymethylcellulose (CMC);

(j) 10-40 wt % Silica (total);

(k) 1-4 wt % Tetrasodium Pyrophosphate (TSPP);

(l) 0.5-1.5 wt % Sodium acid pyrophosphate (SAPP);

(m) 1-4 wt % Sodium Tripolyphosphate (STPP);

(n) 1.2-2.5 wt % Sodium lauryl sulfate (SLS);

(o) 0.5-2 wt % Cocamidopropyl betaine.

17. The oral care composition of claim 16 comprising:

(a) 1.1-1.5 wt. % or 1.8-2.2 wt. % citric acid;

(b) 2.9-3.1 wt % Trisodium citrate;

(c) 0.9-1.1 wt % Zinc oxide;

(d) 0.4-0.6% wt % Stannous fluoride;

(e) 10-50 wt % Glycerin;

(f) 6-8 wt % Propylene glycol; optionally comprising one or more of:

(g) 0.275-0.325 wt % xanthan gum;

(h) 0.25-10 wt % polyvinylpyrrolidone (PVP);

(i) 0.65-0.75 wt. % carboxymethylcellulose (CMC);

(j) 22-26 wt % Silica (total);

(k) 1.75-2.25 wt % Tetrasodium Pyrophosphate (TSPP);

(l) 0.9-1.1 wt % Sodium acid pyrophosphate (SAPP);

(m) 2.75-3.25 wt % Sodium Tripolyphosphate (STPP);

(n) 1.5-1.75 wt % Sodium lauryl sulfate (SLS);

(o) 0.75 to 1.25 wt % Cocamidopropyl betaine.

18. A method of treating a disease or condition of the oral cavity comprising contacting an oral cavity surface of a patient in need thereof with the composition of claim 1 .

19. The method of claim 18 , wherein the disease or condition of the oral cavity is biofilm formation, plaque formation, oral inflammation or a combination thereof.