Composition and method for affecting cytokines and NF-κB
The present invention discloses a composition and method for effecting various cytokines and NF-κB by administering an effective amount of a phyto-percolate composition to an individual. In various exemplary embodiments, the composition is claimed to be useful for the effective treatment of inflammation, cancer, and/or various infections including HIV by regulation of various interleukins, such as IL-10 and IL-2, and of transcription factors including NF-κB.
1. A method of treating inflammation in a subject in need thereof; the method comprising administering to said subject an effective amount of phyto-percolate derived from culturing microorganisms of ATCC Deposit #PTA-5863 wherein the inflammation is treated by the phyto-percolate up regulating anti-inflammatory cytokines while down regulating pro-inflammatory cytokines.
2. The method of claim 1 , wherein the anti-inflammatory cytokines comprise IL-10 and the inflammatory cytokines comprise IL-2.
3. The method of claim 1 , wherein the inflammatory cytokines comprise TNF-α.
4. The method of claim 1 , wherein the inflammatory cytokines comprise IFN-γ.
5. The method of claim 1 , wherein the anti-inflammatory cytokines comprise IL-10 and the inflammatory cytokines comprise IL-2, TNF-α, and IFN-γ.
6. The method of claim 1 , wherein the phyto-percolate affects the expression of cytokines on a cellular level.
7. The method of claim 1 , wherein the phyto-percolate further affects the activation of NF-κB.
8. A method of affecting NF-κB in a subject in need thereof; said method comprising administering to said subject an effective amount of phyto-percolate derived from culturing microorganisms of ATCC Deposit #PTA-5863 to reduce the overall amount of NF-κB.
9. The method of claim 8 , wherein the affecting of NF-κB occurs by decreasing expression, activation or the DNA-binding activity of NF-κB.
10. The method of claim 8 , wherein the affecting of NF-κB reduces inflammation.
11. The method of claim 8 , wherein the affecting of NF-κB results in affecting various viruses.
12. The method of claim 11 , wherein the viruses comprise the HIV virus.
13. The method of claim 8 , wherein the affecting of NF-κB treats disorders of the immune system, including cancer.
14. The method of claim 8 , wherein the affecting of NF-κB affects host immune response.
15. A method of affecting cytokines in a subject in need thereof; said method comprising administering to said subject an effective amount of phyto-percolate derived from culturing microorganisms of ATCC Deposit #PTA-5863 to selectively target and up regulate certain cytokines while down regulating other cytokines to have a specific effect that is achieved by the up regulation and down regulation of various cytokines.
16. The method of claim 15 , wherein the cytokines affected comprise interleukins.
17. The method of claim 15 , wherein the cytokines affected comprise TNF-α.
18. The method of claim 15 , wherein the cytokines affected comprise IL-2, IL-10, IL-17A, and IL-17 and the affecting of the IL-2, IL-10, IL-17A, and IL-17 results in the regulation of the immune response.
19. A method of treating mastitis in a cow, said method comprising administering to said subject to said cow a therapeutically effective amount of one or more isolates or fractions of phyto-percolate derived from culturing microorganisms of ATCC Deposit No. PTA-5863.