Anti-acne formulation
A composition for the treatment of acne includes hydrolyzed Psoralea Corylifolia , containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In a specific implementation, the composition is a water-based acne gel. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.
1. A method of preparing an aqueous mixture comprising:
providing a first mixture, wherein the first mixture is uniformly mixed, is aqueous, and at a temperature of about 40 to about 45 degrees Celsius;
providing an unsolubilized hydrolyzed Psoralea corylifolia extract; and
solubilizing the unsolubilized hydrolyzed Psoralea corylifolia extract comprising:
mixing the unsolubilized hydrolyzed Psoralea corylifolia extract, bisabolol, and polysorbate 20 to obtain a second mixture, and
adding the second mixture to the first mixture to obtain a third mixture, wherein the third mixture is at a temperature from 40 to 45 degrees Celsius, and the third mixture is an aqueous mixture comprising a solubilized hydrolyzed Psoralea corylifolia extract.
2. A method of preparing an aqueous mixture comprising mixing first constituents to obtain a first mixture:
solubilizing an unsolubilized hydrolyzed Psoralea corylifolia extract to obtain a solubilized hydrolyzed Psoralea corylifolia extract comprising mixing the unsolubilized hydrolyzed Psoralea corylifolia extract and bisabolol to obtain a second mixture, and adding the second mixture to the first mixture at a temperature from 40 to 45 degrees Celsius to obtain a third mixture, wherein the third mixture comprises the solubilized hydrolyzed Psoralea corylifolia extract;
allowing the third mixture to cool to about 35 degrees Celsius; and
obtaining an aqueous mixture that is a combination of the first and second mixtures, wherein the aqueous mixture is an anti-acne formulation.
3. The method of claim 2 wherein the first constituents comprise deionized water and hydroxyethylcellulose.
4. The method of claim 3 wherein the first constituents comprise isodium ethylenediaminetetraacetic acid (EDTA) and sodium pyrrolidone carboxylic acid (PCA).
5. The method of claim 4 wherein the first constituents comprise butylene glycol and salicylic acid.
6. The method of claim 5 wherein the first constituents comprise glycolic acid and lactic acid.
7. The method of claim 6 wherein the first constituents comprise sodium hydroxide.
8. The method of claim 7 wherein the first constituents comprise perilla ocymoides leaf extract.
9. The method of claim 8 wherein the first constituents comprise olea europaea fruit extract.
10. The method of claim 9 wherein the first constituents comprise sodium benzoate.
11. The method of claim 2 wherein the first constituents do not comprise an oil constituent.
12. The method of claim 2 wherein the first constituents do not comprise an alcohol constituent.
13. The method of claim 2 wherein the first constituents comprise at least one of polysorbate 20, caprylyl glycol, ethylhexylglycerin, or dipropylene glycol isoceteth-20 acetate.
14. The method of claim 2 wherein the second mixture comprises polysorbate 20.
15. A method of preparing a mixture comprising:
mixing first constituents to obtain a first mixture at a temperature of about 40 to about 45 degrees Celsius;
solubilizing an unsolubilized bakuchiol to obtain a solubilized hydrolyzed bakuchiol comprising mixing the unsolubilized hydrolyzed bakuchiol and bisabolol to obtain a second mixture, and adding the second mixture to the first mixture at a temperature from 40 degrees Celsius to 45 degrees Celsius to 40 degrees Celsius to obtain a third mixture, wherein the third mixture comprises the solubilized hydrolyzed bakuchiol;
allowing the third mixture to cool to a temperature less than that at which the second mixture was added to the first mixture; and
obtaining a mixture that is a combination of the first and second mixtures, wherein the aqueous mixture is an anti-acne formulation.
16. The method of claim 15 wherein the mixture is an aqueous mixture and the first mixture comprises water, and the first mixture does not comprise an alcohol constituent.
17. The method of claim 15 wherein the second mixture is added to the first mixture at a temperature below about 45 degrees Celsius.
18. The method of claim 16 wherein the second mixture is added to the first mixture at a temperature below about 45 degrees Celsius.
19. The method of claim 15 wherein the second mixture is added to the first mixture at a temperature of 40 degrees Celsius or above and below about 45 degrees Celsius.
20. The method of claim 15 wherein the anti-acne formulation is a water-based gel and does not include an alcohol.