Anti-IL-23 antibodies
The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.
1. A method for treating a subject having a disorder associated with increased interleukin 23 (IL-23) expression comprising administering to the subject an anti-IL-23p19 antibody or antigen-binding fragment or a pharmaceutical composition comprising an anti-IL-23p19 antibody or antigen-binding fragment and a pharmaceutically acceptable carrier, which antibody or antigen-binding fragment binds to human IL-23, wherein the antibody or antigen-binding fragment thereof comprises: a) a light chain variable region comprising the amino acid sequence of SEQ ID NO:19 (CDR1-L); the amino acid sequence of SEQ ID NO:20 (CDR2-L); and the amino acid sequence of SEQ NO:21 (CDR3-L); and b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 63, 66, 67 or 68 (CDR1-H); the amino acid sequence of SEQ ID NO:64 (CDR2-H); and the amino acid sequence of SEQ ID NO:65 (CDR3-H).
2. The method of claim 1 , wherein the anti-IL-23p19 antibody or antigen-binding fragment comprises a light chain variable region comprising an amino acid sequence of SEQ ID NO: 160 and a heavy chain variable region comprising an amino acid sequence of SEQ ID NO: 166.
3. The method of claim 1 , wherein the anti-IL-23p19 antibody or antigen-binding fragment comprises a light chain comprising an amino acid sequence of SEQ ID NO: 174 and a heavy chain comprising an amino acid sequence of SEQ ID NO: 176.
4. A method for treating an inflammatory disease, an autoimmune disease, or cancer comprising administering to a subject in need thereof an effective amount of an anti-IL-23p19 antibody or antigen-binding fragment or a pharmaceutical composition comprising an anti-IL-23p19 antibody or antigen-binding fragment and a pharmaceutically acceptable carrier, wherein the antibody or antigen-binding fragment thereof comprises: a) a light chain variable region comprising the amino acid sequence of SEQ ID NO:19 (CDR1-L); the amino acid sequence of SEQ ID NO:20 (CDR2-L); and the amino acid sequence of SEQ ID NO:21 (CDR3-L); and b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 63, 66, 67 or 68 (CDR1-H); the amino acid sequence of SEQ ID NO:64 (CDR2-H); and the amino acid sequence of SEQ ID NO:65 (CDR3-H).
5. The method of claim 4 , wherein the anti-IL-23p19 antibody or antigen-binding fragment comprises a light chain variable region comprising an amino acid sequence of SEQ ID NO: 160 and a heavy chain variable region comprising an amino acid sequence of SEQ ID NO: 166.
6. The method of claim 4 , wherein the anti-IL-23p19 antibody or antigen-binding fragment comprises a light chain comprising an amino acid sequence of SEQ ID NO: 174 and a heavy chain comprising an amino acid sequence of SEQ ID NO: 176.
7. A method for inhibiting the binding of IL-23 to the IL-23 receptor on a mammalian cell, comprising administering to the cell an anti-IL-23p19 antibody or antigen-binding fragment, whereby signaling mediated by the IL-23 receptor is inhibited, wherein the antibody or antigen-binding fragment thereof comprises:
a) a light chain variable region comprising the amino acid sequence of SEQ ID NO:19 (CDR1-L); the amino acid sequence of SEQ ID NO:20 (CDR2-L); and the amino acid sequence of SEQ ID NO:21 (CDR3-L); and
b) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 63, 66, 67 or 68 (CDR1-H); the amino acid sequence of SEQ ID NO:64 (CDR2-H); and the amino acid sequence of SEQ ID NO:65 (CDR3-H).
8. The method of claim 7 , wherein the anti-IL-23p19 antibody or antigen-binding fragment comprises a light chain variable region comprising an amino acid sequence of SEQ ID NO: 160 and a heavy chain variable region comprising an amino acid sequence of SEQ ID NO: 166.
9. The method of claim 7 , wherein the anti-IL-23p19 antibody or antigen-binding fragment comprises a light chain comprising an amino acid sequence of SEQ ID NO: 174 and a heavy chain comprising an amino acid sequence of SEQ ID NO: 176.