Cell adhesion inhibitor
Provided is a cell adhesion inhibitor which exhibits low cytotoxicity and an excellent cell adhesion prevention effect; a tool and an apparatus each having a surface modified through application of the cell adhesion inhibitor thereto; a method for producing each of the surface-modified tool and apparatus; a biomedical structure and a production method therefor; and a microchannel device and a production method therefor. The invention provides a cell adhesion inhibitor comprising, as an active ingredient, a polymer comprising a repeating unit having a sulfinyl group in a side chain thereof.
1. A surface-modified tool having, on at least a portion of a surface thereof, a polymer comprising a repeating unit represented by the following formula (1):
wherein R 3 represents a copolymer unit obtained by copolymerization of an acrylate monomer with a styrene monomer and R 4 represents a monovalent group represented by the following formula (5) which includes one or more hydroxyl groups attached to a sulfinyl group,
wherein k 1 is an integer of 1 to 4; k 2 is an integer of 0 to 4; and *** denotes the position of bonding to a sulfur atom in formula (1).
2. The surface-modified tool according to claim 1 , wherein the polymer further comprises a hydrophobic repeating unit.
3. The surface-modified tool according to claim 1 , wherein said surface-modified tool is a biomedical structure.
4. The surface-modified tool according to claim 1 , wherein said surface-modified tool is a microchannel device.
5. A surface-modified apparatus, having on at least a portion of a surface thereof, a polymer comprising a repeating unit represented by the following formula (1):
wherein R 3 represents a copolymer unit obtained by copolymerization of an acrylate monomer with a styrene monomer and R 4 represents a monovalent group represented by the following formula (5) which includes one or more hydroxyl groups attached to a sulfinyl group,
wherein k 1 is an integer of 1 to 4; k 2 is an integer of 0 to 4; and *** denotes the position of bonding to a sulfur atom in formula (1).
6. The surface-modified apparatus according to claim 5 , wherein the polymer further comprises a hydrophobic repeating unit.
7. The surface-modified apparatus according to claim 5 , wherein said surface-modified apparatus is a biomedical structure.
8. The surface-modified apparatus according to claim 5 , wherein said surface-modified apparatus is a microchannel device.