Medical fluid, a method of treatment and use of the fluid
A medical fluid for a harvested organ, tissue or part thereof, for evaluation and/or preservation. The fluid includes cocaine or a stimulating analog thereof; noradrenaline; and/or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenaline; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.
1. A method for preservation and/or evaluation of a harvested organ comprising:
circulating a medical fluid in the vascular system of the harvested organ, wherein:
the medical fluid comprises: cocaine or a cocaine analogue with stimulating effect; adrenaline; and noradrenaline; and
the harvested organ is at least partly denervated,
wherein the cocaine or the cocaine analogue is present in the medical fluid at a concentration of 0.010 μM to 0.100 μM.
2. The method according to claim 1 , wherein the medical fluid further comprises: an oncotic agent; and electrolytes in physiological concentrations in a physiologically acceptable medium.
3. The method according to claim 1 , wherein the adrenaline and the noradrenaline are present in the medical fluid at concentrations that are subphysiological.
4. The method according to claim 1 , wherein:
the adrenaline is present in the medical fluid at a concentration of 0.010 μM to 0.100 μM; and
the noradrenaline is present in the medical fluid at a concentration of 0.010 μM to 0.100 μM.
5. The method according to claim 1 , wherein the cocaine or the cocaine analogue, the adrenaline, and the noradrenaline are present in the medical fluid at concentrations that are equimolar.
6. The method according to claim 1 , wherein the harvested organ comprises a lung, lungs, or a heart.
7. The method according to claim 1 , wherein:
the medical fluid further comprises: an oncotic agent; and electrolytes in physiological concentrations in a physiologically acceptable medium; and
the adrenaline and the noradrenaline are present in the medical fluid at concentrations that are subphysiological.
8. The method according to claim 1 , wherein:
the medical fluid further comprises: an oncotic agent; and electrolytes in physiological concentrations in a physiologically acceptable medium;
the adrenaline is present in the medical fluid at a concentration of 0.010 μM to 0.100 μM; and
the noradrenaline is present in the medical fluid at a concentration of 0.010 μM to 0.100 μM.
9. The method according to claim 8 , wherein the harvested organ comprises a lung, lungs, or a heart.
10. The method according to claim 1 , wherein:
the medical fluid further comprises: an oncotic agent; and electrolytes in physiological concentrations in a physiologically acceptable medium; and
the cocaine or the cocaine analogue, the adrenaline, and the noradrenaline are present in the medical fluid at concentrations that are equimolar.
11. The method according to claim 1 , wherein the medical fluid comprises the cocaine.
12. The method according to claim 11 , wherein the medical fluid further comprises: an oncotic agent; and electrolytes in physiological concentrations in a physiologically acceptable medium.
13. The method according to claim 11 , wherein the adrenaline and the noradrenaline are present in the medical fluid at concentrations that are subphysiological.
14. The method according to claim 11 , wherein:
the adrenaline is present in the medical fluid at a concentration of 0.010 μM to 0.100 μM; and
the noradrenaline is present in the medical fluid at a concentration of 0.010 μM to 0.100 μM.
15. The method according to claim 11 , wherein the cocaine, the adrenaline, and the noradrenaline are present in the medical fluid at concentrations that are equimolar.
16. The method according to claim 11 , wherein the harvested organ comprises a lung, lungs, or a heart.