Abuse potential reduction in abusable substance dosage form
The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.
1. A system for reducing potential for abuse of a substance, the system comprising:
(a) the substance; and
(b) a container comprising an anti-abuse layer attached to a side of the container.
2. The system according to claim 1 , wherein the anti-abuse layer comprises an absorbent material.
3. The system according to claim 2 , wherein the absorbent material comprises activated carbon.
4. The system according to claim 1 , wherein the container comprises a pouch.
5. The system according to claim 1 , wherein the container comprises a closure system configured to seal the container.
6. The system according to claim 5 , wherein the closure system comprises an adhesive.
7. The system according to claim 5 , wherein the closure system comprises a ziplock.
8. The system according to claim 1 , wherein the substance is an opioid.
9. The system according to claim 8 , herein the opioid is fentanyl.
10. The system according to claim 1 , wherein the anti-abuse layer comprises an anti-abuse substance selected from the group consisting of co-soluble antagonists, irritants and combinations thereof.
11. The system according to claim 10 , wherein the anti-abuse substance includes an amount of an antagonist.
12. The system according to claim 10 , wherein the anti-abuse substance includes an amount of an irritant.
13. A system for reducing potential for abuse of a substance, the system comprising:
(a) the substance; and
(b) a pouch comprising:
(i) an anti-abuse layer comprising an absorbent material attached to a side of the pouch; and
(ii) a closure system at an opening of the pouch.
14. The system according to claim 13 , wherein the absorbent material comprises activated carbon.
15. The system according to claim 13 , wherein the closure system comprises an adhesive.
16. The system according to claim 13 , wherein the substance is an opioid.
17. The system according to claim 16 , wherein the opioid is fentanyl.
18. The system according to claim 13 , wherein the anti-abuse layer further comprises an anti-abuse substance selected from the group consisting of co-soluble antagonists, irritants and combinations thereof.
19. The system according to claim 18 , wherein the anti-abuse substance includes an amount of an antagonist.
20. The system according to claim 18 , wherein the anti-abuse substance includes an amount of an irritant.
21. A system for reducing potential for abuse of a fentanyl composition, the system comprising:
(a) a fentanyl composition; and
(b) a pouch comprising:
(i) an anti-abuse layer comprising activated carbon attached to a side of the pouch; and
(ii) a closure system comprising an adhesive at an opening of the pouch.