Compositions and methods for antibodies targeting complement protein C5
The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
1. A method of inhibiting membrane attack complex (MAO formation in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising an isolated antibody or antigen binding fragment thereof that specifically binds to a human complement C5 protein, said antibody or antigen binding fragment thereof comprising an HCDR1 sequence comprising the sequence of SEQ ID NO: 1, an HCDR2 sequence comprising the sequence of SEQ ID NO: 2, an HCDR3 sequence comprising the sequence of SEQ ID NO: 3, an LCDR1 sequence comprising the sequence of SEQ ID NO: 4, an LCDR2 sequence comprising the sequence of SEQ ID NO: 5, and an LCDR3 sequence comprising the sequence of SEQ ID NO: 6, wherein the subject has asthma, arthritis, autoimmune heart disease, multiple sclerosis, inflammatory bowel disease, ischemia-reperfusion injuries, Barraquer-Simons Syndrome, hemodialysis, systemic lupus, lupus erythematosus, psoriasis, multiple sclerosis, a transplantation, glomerulonephritis, or MPGN II.
2. The method of claim 1 , wherein the antibody, or antigen binding fragment, further comprises a heavy chain variable region having 95% sequence identity to SEQ ID NO: 7.
3. The method of claim 1 wherein the antibody, or antigen binding fragment, further comprises a heavy chain variable region having the sequence of SEQ ID NO: 7.
4. The method of claim 1 , wherein the antibody, or antigen binding fragment, further comprises a light chain variable region having 95% sequence identity to SEQ ID NO: 8.
5. The method of claim 3 , wherein the antibody, or antigen binding fragment, further comprises a light chain variable region having the sequence of SEQ ID NO:8.
6. The method of claim 1 , wherein the antibody, or antigen binding fragment, further comprises a heavy chain having 95% sequence identity to SEQ ID NO: 9.
7. The method of claim 1 , wherein the antibody, or antigen binding fragment, further comprises a heavy chain having the sequence of SEQ ID NO: 9.
8. The method of claim 1 , wherein the antibody, or antigen binding fragment, further comprises a light chain having 95% sequence identity to SEQ ID NO: 10.
9. The method of claim 7 , wherein the antibody, or antigen binding fragment, further comprises a light chain having the sequence of SEQ ID NO: 10.
10. The method of claim 1 , wherein said subject is a human.
11. The method of claim 1 , wherein the MAC inhibition is associated with transplantation.
12. The method of claim 9 , wherein the MAC inhibition is associated with transplantation.