Composition and methods for treating ischemic wounds and inflammatory conditions
Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.
1. A method of treating an inflammatory condition comprising a chronic or ischemic site of inflammation in a patient suffering from said inflammatory condition, said method comprising:
topically applying or injecting, for a therapeutically effective period of time, a therapeutically effective amount of a modified collagen gel composition to said site of inflammation,
wherein said modified collagen is a hydrolyzed bovine collagen, wherein said modified collagen gel comprises a plurality of proteins comprising Hemoglobin subunit beta, Carbonic anhydrase 2, Collagen alpha-1 (1) chain, Hemoglobin subunit alpha, Peroxire doxin-2, Alpha-1-antiproteinase, Serpin A3-7, Collagen alpha-1(III) chain, Collagen alpha-2(I) chain, Serpin A3-3, Actin, and aortic smooth muscle, and reduces said inflammatory condition in said patient.
2. The method of claim 1 , wherein said site of inflammation is a site of dermal inflammation.
3. The method of claim 1 , wherein said reduction of inflammation comprises action by said collagen gel to up-regulate anti-inflammatory cytokines of said patient to thereby reduce inflammation in said inflammatory condition of said patient.
4. The method of claim 1 , wherein said modified collagen gel increases the ratio of the patient's collagen type I to collagen type III at said site of inflammation.
5. The method of claim 1 , wherein said modified collagen gel composition comprises a dispersion of about 52% by weight hydrolyzed bovine collagen, dispersed in an aqueous matrix comprising water and glycerine.
6. The method of claim 1 , wherein said modified collagen gel composition comprises from about 25 to about 75%, by weight modified collagen, based upon the total weight of the composition taken as 100% by weight.
7. The method of claim 1 , said modified collagen gel comprises modified collagen of long and short polypeptides dispersed in an aqueous matrix.
8. The method of claim 1 , wherein said modified collagen gel comprises from about 25 to about 75% by weight modified collagen dispersed in an aqueous matrix, based upon the total weight of the gel composition taken as 100% by weight.