Sphingosine kinase type 1 inhibitors and uses thereof
Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.
1. A method for treating asthma in a patient, comprising:
administering to a patient in need of treatment for asthma a compound having the formula
2. The method of claim 1 , wherein the administering step comprises administering to the patient the compound having the formula
3. The method of claim 2 , wherein the administering step comprises administering to the patient
4. A method for treating asthma in a patient, comprising:
administering to a patient in need of treatment for asthma a compound having the formula
wherein R comprises a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
5. The method of claim 4 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, a hetero-aromatic ring, or any combination of the foregoing.
6. The method of claim 5 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, a branched carbon chain comprising one or more heteroatoms, a cyclic ring, a heterocyclic ring, an aromatic ring, or a hetero-aromatic ring.
7. The method of claim 6 , wherein R is a straight carbon chain, a branched carbon chain, a straight carbon chain comprising one or more heteroatoms, or a branched carbon chain comprising one or more heteroatoms.
8. The method of claim 7 , wherein R is a straight carbon chain or a branched carbon chain.
9. The method of claim 8 , wherein R is a straight carbon chain.