Oral care compositions
Provided are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride and a pyrophosphate salt and oral care compositions comprising the complexes and uses thereof.
1. An oral care composition comprising an aqueous soluble tin phosphate complex formed from a mixture comprising tin (II) fluoride, and a pyrophosphate salt; wherein the complex comprises tin, phosphate and fluoride; and wherein the complex is formed from a mixture comprising the tin (II) fluoride and pyrophosphate salt in a molar ratio of 1P:1Sn to 10P:1Sn, and wherein the complex is present in an amount of 2 to 30 weight % by weight of the composition, wherein the complex is formed in situ in an aqueous solution and combined with an oral care base, or wherein the complex is isolated from the aqueous solution in solid form and combined with the oral care base, or wherein the complex is lyophilized and combined with the oral care base, or wherein the complex is isolated with an anti-solvent and combined with the composition.
2. The composition of claim 1 , wherein the oral care base is a mouthwash base, an oral gel or a dentifrice base.
3. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride by weight of the mixture and 1 to 40 weight % pyrophosphate salt by weight of the mixture.
4. The composition of claim 1 , wherein the pyrophosphate salt is tetrapotassium pyrophosphate (K 4 P 2 O 7 ).
5. The composition of claim 4 , wherein the complex is formed from a mixture comprising the tin (II) fluoride and tetrapotassium pyrophosphate in a molar ratio of at least 1P:1Sn.
6. The composition of claim 4 , wherein the complex is formed from a mixture comprising the tin (II) fluoride and tetrapotassium pyrophosphate in a molar ratio of 1P:1Sn to 10P:1Sn.
7. The composition of claim 4 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride by weight of the mixture and 1 to 40 weight % tetrapotassium pyrophosphate by weight of the mixture.
8. The composition of claim 1 , wherein the pyrophosphate salt is tetrasodium pyrophosphate (Na 4 P 2 O 7 ).
9. The composition of claim 8 , wherein the complex is formed from a mixture comprising the tin (II) fluoride and tetrasodium pyrophosphate in a molar ratio of 1P:1Sn to 5P:1Sn.
10. The composition of claim 8 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride by weight of the mixture and 1 to 30 weight % tetrasodium pyrophosphate by weight of the mixture.
11. The composition of claim 8 , wherein the tin (II) fluoride and tetrasodium pyrophosphate (Na 4 P 2 O 7 ) form a complex having the formula [P 2 O 7 ] 4− Na 2+ Sn 2+ 2 F − .
12. The composition of claim 1 , wherein the composition comprises an aqueous solution.
13. The composition of claim 1 further comprising more than 20 weight % water by weight of the composition.
14. The composition of claim 1 , wherein the composition is a mouthwash.
15. The composition of claim 1 for use to reduce dentinal hypersensitivity.
16. A method to reduce or inhibit dentinal hypersensitivity, dental caries, gingivitis, or plaque in a person in need thereof comprising applying an effective amount of an oral care composition as claimed in claim 1 to teeth of the person.