IP Library › Granted Patent US 12,617,710
Granted Patent B2
US 12,617,710 · App. 17/980,955 · Granted May 5, 2026

Glass compositions with improved bioactivity

Inventors: Qiang Fu (Painted Post, NY); Aize Li (Painted Post, NY); Charisse Marye Spier (Horseheads, NY)
Assignee: CORNING INCORPORATED
C03C3/087
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Quick Facts
Patent No.
US 12,617,710
App. No.
17/980,955
Granted
May 5, 2026
Kind
B2
Abstract

A silicate-based glass composition includes 15-65 wt. % SiO 2 , 15-50 wt. % CaO, 1-30 wt. % P 2 O 5 , and 1-20 wt. % ZrO 2 , such that the composition has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms a bioactive crystalline phase in simulated body fluid.

Claims (41)

1 . A silicate-based glass composition, comprising:

15-65 wt. % SiO 2 ,

15-50 wt. % CaO,

10-30 wt. % P 2 O 5 ,

1-20 wt. % ZrO 2 , and

0-7 wt. % MgO,

wherein the composition has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms a bioactive crystalline phase in simulated body fluid.

2 . The glass composition of claim 1 , comprising:

15-45 wt. % SiO 2 ,

30-50 wt. % CaO, and

2-15 wt. % ZrO 2 .

3 . The glass composition of claim 2 , further comprising 3-6 wt. % MgO.

4 . The glass composition of claim 2 , further comprising 10-20 wt. % SrO.

5 . The glass composition of claim 2 , further comprising 10-20 wt. % ZnO.

6 . The glass composition of claim 1 , further comprising >0-6 wt. % MgO.

7 . The glass composition of claim 1 , further comprising >0-25 wt. % SrO.

8 . The glass composition of claim 1 , further comprising >0-25 wt. % ZnO.

9 . The glass composition of claim 1 , wherein the glass comprises:

15-50 wt. % MO, and

0-30 wt. % R 2 O,

wherein MO is the sum of MgO, CaO, SrO, BeO, and BaO, and R 2 O is the sum of Na 2 O, K 2 O, Li 2 O, Rb 2 O, and Cs 2 O.

10 . The glass composition of claim 1 , wherein the bioactive crystalline phase comprises apatite.

11 . The glass composition of claim 10 , wherein the apatite is hydroxyapatite.

12 . The glass composition of claim 1 , wherein a sum of P 2 O 5 and CaO is from 25-65 wt. %.

13 . The glass composition of claim 1 , wherein the simulated body fluid is an artificial saliva.

14 . A matrix comprising the glass composition of claim 1 , wherein:

the glass composition is attached to the matrix or mixed therein, and

the matrix includes at least one of: a toothpaste, mouthwash, rinse, spray, ointment, salve, cream, bandage, polymer film, oral formulation, pill, capsule, or transdermal formulation.

15 . An aqueous environment comprising the glass composition of claim 1 .

16 . A silicate-based glass composition, comprising:

15-45 wt. % SiO 2 ,

30-60 wt. % CaO,

10-30 wt. % P 2 O 5 , and

2-15 wt. % ZrO 2 , and

0-7 wt. % MgO,

wherein the composition has a hydrolytic resistance of glass grains (HGB) of at most 3, when measured by International Organization for Standardization section 719 (ISO 719), and forms an apatite crystalline phase in an artificial saliva, and

wherein a sum of P 2 O 5 and CaO is from 25-65 wt. %.

17 . The glass composition of claim 16 , further comprising 3-6 wt. % MgO.

18 . The glass composition of claim 16 , further comprising 10-20 wt. % SrO.

19 . The glass composition of claim 16 , further comprising 10-20 wt. % ZnO.

20 . The glass composition of claim 16 , wherein the apatite is hydroxyapatite.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 19, 2024
From: FU, QIANG; LI, AIZE; SPIER, CHARISSE MARYE
To: CORNING INCORPORATED
Reel/Frame 066823/0167 →
Continuity (2)
Provisional Application 63275507 · Nov 4, 2021
Related Publication 20230133219A1 · May 4, 2023
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