Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
1. A method for delaying the onset of or treating a disease selected from Alzheimer's disease and Parkinson's disease comprising administering to a patient in need thereof a pharmaceutically effective amount of a sulphate salt of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine or a pharmaceutically acceptable solvate thereof.
2. The method according to claim 1 , wherein the method is for treating a disease, and the disease is Parkinson's disease.
3. The method according to claim 1 , wherein the method is for delaying the onset of a disease, and the disease is Alzheimer's disease.
4. The method according to claim 1 wherein the sulphate salt has Formula II
wherein x designates the number of equivalents of sulphuric acid and x is 0.5 to 4, or a pharmaceutically acceptable solvate thereof.
5. The method according to claim 2 wherein the sulphate salt has Formula II
wherein x designates the number of equivalents of sulphuric acid and x is 0.5 to 4, or a pharmaceutically acceptable solvate thereof.
6. The method according to claim 3 wherein the sulphate salt has Formula II
wherein x designates the number of equivalents of sulphuric acid and x is 0.5 to 4, or a pharmaceutically acceptable solvate thereof.
7. A method according to claim 1 wherein the method is for treating a disease, and the disease is Alzheimer's disease.
8. A method according to claim 1 wherein the method is for delaying the onset of a disease, and the disease is Parkinson's disease.
9. The method according to claim 7 wherein the sulphate salt has Formula II
wherein x designates the number of equivalents of sulphuric acid and x is 0.5 to 4, or a pharmaceutically acceptable solvate thereof.
10. The method according to claim 8 wherein the sulphate salt has Formula II
wherein x designates the number of equivalents of sulphuric acid and x is 0.5 to 4, or a pharmaceutically acceptable solvate thereof.