IP Library › Granted Patent US 10,556,905
Granted Patent B2
US 10,556,905 · App. 15/973,861 · Granted Feb 11, 2020

Processes for preparing a diazabicyclooctane compound

Inventors: Takao Abe (Kanagawa, JP); Takeshi Furuuchi (Kanagawa, JP); Yoshiaki Sakamaki (Kanagawa, JP); Seiichi Inamura (Kanagawa, JP); Akihiro Morinaka (Kanagawa, JP)
Assignee: MEIJI SEIKA PHARMA CO., LTD.
C07D471/08A61K31/407A61K31/4162A61K31/427A61K31/43A61K31/437A61K31/439A61K31/444A61K31/4545A61K31/5377A61K31/545A61K31/546A61K45/06C07D211/60C07F7/0812Y02P20/55
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Quick Facts
Patent No.
US 10,556,905
App. No.
15/973,861
Granted
Feb 11, 2020
Kind
B2
Abstract

A process for preparing a diazabicyclooctane compound represented by the following formula (I): wherein A represents RcO—; B represents NH or NC 1-6 alkyl; C represents a benzyl group; Rc represents a C 1-6 alkyl group; A is substituted with one substituent Fn1, wherein Fn1 represents an azetidine group; the process including: (a) silylating the compound represented by the following formula (IV-c): wherein in the formula (IV-c), OBn represents benzyloxy, and (b) carrying out an intramolecular urea formation reaction.

Claims (18)

1. A compound of a formula selected from the group consisting of

wherein in the above formulae, TFA represents a trifluoroacetyl group, OMe represents a methoxy group, Boc represents a tert-butoxycarbonyl group, Teoc represents a 2-trimethylsilylethoxycarbonyl group, OBn represents a benzyloxy group, and Cbz represents a benzyloxycarbonyl group.

2. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group and TFA represents a trifluoroacetyl group.

3. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group and Boc represents a tert-butoxycarbonyl group.

4. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group and Teoc represents a 2-trimethylsilylethoxycarbonyl group.

5. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group, Boc represents a tert-butoxycarbonyl group and Teoc represents a 2-trimethylsilylethoxycarbonyl group.

6. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group, Boc represents a tert-butoxycarbonyl group and Cbz represents a benzyloxycarbonyl group.

7. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group, Boc represents a tert-butoxycarbonyl group and Teoc represents a 2-trimethylsilylethoxycarbonyl group.

8. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group and Boc represents a tert-butoxycarbonyl group.

9. The compound of claim 1 , which has the formula

wherein OBn represents a benzyloxy group and Cbz represents a benzyloxycarbonyl group.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 8, 2018
From: ABE, TAKAO; FURUUCHI, TAKESHI; SAKAMAKI, YOSHIAKI; INAMURA, SEIICHI; MORINAKA, AKIHIRO
To: MEIJI SEIKA PHARMA CO., LTD.
Reel/Frame 045743/0770 →
Priority Claims (1)
JP 2012-122603 · May 30, 2012 · national
Continuity (4)
Division 15583238 · May 1, 2017
Division 14872988 · Oct 1, 2015
Division 14404288
Related Publication 20180258089A1 · Sep 13, 2018
Cited By (1)
US 12,221,443