IP Library › Granted Patent US 10,610,607
Granted Patent B2
US 10,610,607 · App. 15/644,172 · Granted Apr 7, 2020

Magnetic graphene-like nanoparticles or graphitic nano- or microparticles and method of production and uses thereof

Inventors: Balaji Sitharaman (Coram, NY); Bhavna S. Paratala (Karnataka, IN)
Assignee: The Research Foundation for The State University of New York
A61K49/10B82Y15/00B82Y30/00B82Y40/00C01B32/184C01B32/192A61K49/0095C01B2204/20
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Quick Facts
Patent No.
US 10,610,607
App. No.
15/644,172
Granted
Apr 7, 2020
Kind
B2
Abstract

The present invention provides a magnetic graphene-like nanoparticle or graphitic nano- or microparticle. The magnetic graphene-like nanoparticle or graphitic nano- or microparticle of the invention exhibits a high relaxivity, and is useful as a MRI contrast agent. The present invention also provides a composition for use with MRI imaging, comprising a sufficient amount of the magnetic graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. The present invention also provides methods of using the magnetic graphene-like nanoparticles or graphitic nano- or microparticles as MRI contrast agents. The present invention further provides methods of producing the magnetic graphene-like nanoparticle or graphitic nano- or microparticle.

Claims (8)

1. A composition for use with magnetic resonance imaging, comprising:

(i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano- or microstructure, wherein said magnetic metal comprises Mn, wherein the composition is configured to maintain a water proton relaxivity ratio of r 2 :r 1 <4 and is configured to increase the r 1 relaxivity by a factor of 2 or more as compared to Mn2+ ion in aqueous media; and

(ii) one or more physiologically acceptable carriers or excipients.

2. The composition of claim 1 , wherein said graphitic nano- or microstructure has a thickness of 20 μm or less.

3. The magnetic composition of claim 1 , wherein said graphene-like nanostructure comprises 2 to 12 atomic layers of carbon.

4. The composition of claim 1 , wherein said graphene-like nanostructure is selected from the group consisting of carbon nanoplatelet and carbon nanoribbon.

5. The composition of claim 1 , wherein said graphene-like nanostructure is a carbon nanoribbon having an average width in the range of 1 to 250 nm and an average length in the range of 200 to 5000 nm.

6. The composition of claim 1 , wherein said Mn is present in a Mn oxide.

Continuity (3)
Continuation 14116102
Provisional Application 61483309 · May 6, 2011
Related Publication 20170312374A1 · Nov 2, 2017
Cited By (1)
US 12,329,042