Donepezil derivative and use thereof
The present invention relates to a donepezil derivative of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R in the formula is as disclosed herein; and a method for preparation thereof; and a composition comprising an effective amount of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to use of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof in preparing a medicament for treating a disease resulted from an abnormality in acetylcholinesterase activity.
1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein R is C 6 alkyl group.
2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R is n-hexane.
3. A method of treating dementia in a patient, comprising:
administering to said patient a compound according to claim 1 or the pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition, comprising a compound according to claim 1 or the pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.
5. The pharmaceutical composition of claim 4 , wherein the excipient is selected from one or more of castor oil, soybean oil, sesame oil, arachis oil, corn oil, cottonseed oil, or glycerides.
6. The pharmaceutical composition of claim 4 , further comprising a hydrotropic agent, wherein the hydrotropic agent is selected from one or more of benzyl benzoate or alcohols.
7. The pharmaceutical composition according to claim 4 , further comprising a pain relief agent, wherein the pain relief agent is benzyl alcohol.
8. The pharmaceutical composition of claim 5 , wherein the excipient is castor oil.
9. The pharmaceutical composition of claim 6 , wherein the hydrotropic agent is benzyl benzoate.
10. A method of treating dementia in a patient, comprising:
administering to said patient a pharmaceutical composition comprising a compound according to claim 1 or the pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.
11. The method of claim 10 , wherein the excipient comprises castor oil.
12. The method of claim 10 , wherein the pharmaceutical composition further comprises a hydrotropic agent, wherein the hydrotropic agent is benzyl benzoate.
13. The method of claim 3 , further comprising administering to said patient a pain relief agent, wherein the pain relief agent is benzyl alcohol.
14. The method of claim 10 , further comprising administering to said patient a pain relief agent, wherein the pain relief agent is benzyl alcohol.