IP Library › Granted Patent US 10,646,503
Granted Patent B2
US 10,646,503 · App. 16/582,779 · Granted May 12, 2020

Isotopologues of 5-azacytidine

Inventors: John F. Traverse (Lebanon, NJ); William W. Leong (Westfield, NJ); Jeffrey B. Etter (Boulder, CO); Mei Lai (Longmont, CO); Jay Thomas Backstrom (Leawood, KS)
Assignee: Celgene Corporation
A61K31/706A61K9/2013A61K9/2018A61K9/2846A61K9/2866A61K9/2886A61K31/7068A61K47/10
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Quick Facts
Patent No.
US 10,646,503
App. No.
16/582,779
Granted
May 12, 2020
Kind
B2
Abstract

The present disclosure provides pharmaceutical compositions comprising cytidine analogs for oral administration, wherein the compositions release the cytidine analog substantially in the stomach. Also provided are methods of treating diseases and disorders using the oral formulations provided herein.

Claims (3)

1. A compound of the formula:

or a pharmaceutically acceptable salt thereof, wherein:

Y 3 is a hydrogen isotopically enriched with deuterium, and Y 1 , Y 2 , Y 4 , Y 5 , Y 6 and are non-enriched hydrogen atoms.

Continuity (9)
Continuation 16244014 · Jan 9, 2019
Continuation 15835088 · Dec 7, 2017
Division 14788606 · Jun 30, 2015
Continuation 14463424 · Aug 19, 2014
Continuation 12466213 · May 14, 2009
Provisional Application 61157875 · Mar 5, 2009
Provisional Application 61201145 · Dec 5, 2008
Provisional Application 61053609 · May 15, 2008
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