Apparatus and method for rapid chemical analysis using differential desorption
The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.
1. A device comprising:
(a) a wand including a mesh screen;
(b) a sensor, where the sensor detects contact between the wand in a first target area on the mesh screen and a sample;
(c) a desorption ionization source adapted to direct a stream of energetic particles towards the first target area, where the stream of energetic particles interacting with the first target area generates a plurality of sample ions; and
(d) an analyzer adapted to analyze one or more of the plurality of sample ions.
2. The device of claim 1 , where the mesh screen comprises one or more materials selected from the group consisting of a filament, an impregnated filament, a sorbent coated filament and a mesh.
3. The device of claim 2 , where the sorbent coated filament comprises polyester.
4. The device of claim 3 , where the sorbent coated filament further comprises polytetrafluoroethylene (PTFE).
5. The device of claim 1 , where the desorption ionization source is selected from the group consisting of a DART source, a DESI source, a MALDI source, a UV laser source, an IR laser source, atmospheric pressure chemical ionization (APCI) spray source, directed electrospray source, electrospray source, a dielectric barrier discharge source, and a flowing after-glow plasma source.
6. The device of claim 1 , where the analyzer is a mass spectrometer.
7. The device of claim 1 , where the stream of energetic particles are directed towards the first target area at a first temperature.
8. The device of claim 7 , where the stream of energetic particles are directed towards a second target area at the first temperature.
9. The device of claim 1 , where the sensor is adapted to detect one or both of pressure and temperature.
10. The device of claim 1 , where the sensor detects a change in temperature following contact with the sample.
11. A device comprising:
(a) a wand including a mesh screen comprising a fiber;
(b) a sensor, where the sensor detects contact between the fiber and a sample;
(c) a desorption ionization source adapted to direct a stream of energetic particles towards the fiber, where the stream of energetic particles interacting with the fiber generates a plurality of sample ions; and
(e) an analyzer, adapted to analyze one or more of the plurality of sample ions.
12. The device of claim 11 , where the fiber comprises polyester and PTFE.
13. The device of claim 11 , where the sensor is adapted to detect one or both of pressure and temperature.
14. The device of claim 11 , where the sensor detects a change in temperature following the fiber contacting the sample.
15. A device comprising:
(a) a wand including a mesh screen comprising a first fiber and a second fiber where the first fiber is in close proximity to the second fiber;
(b) a sensor, where the sensor detects physical contact between the wand and a sample in at least the first fiber or the second fiber;
(c) a desorption ionization source adapted to direct a stream of energetic particles towards the first fiber and/or the second fiber, where the stream of energetic particles interacting with one or both the first fiber and the second fiber generates a plurality of sample ions; and
(e) an analyzer, adapted to analyze one or more of the plurality of sample ions.
16. The device of claim 15 , where the first fiber comprises polyester.
17. The device of claim 16 , where the first fiber further comprises PTFE.
18. The device of claim 15 , where the desorption ionization source is selected from the group consisting of a DART source, a DESI source, a MALDI source, a UV laser source, an IR laser source, atmospheric pressure chemical ionization (APCI) spray source, directed electrospray source, electrospray source, a dielectric barrier discharge source, and a flowing after-glow plasma source.
19. The device of claim 15 , where the sensor is adapted to detect one or both of pressure and temperature.
20. The device of claim 1 , where the sensor detects a change in temperature following contact of the mesh screen with the sample.