Treprostinil administration by inhalation
Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
1. A method of treating pulmonary hypertension comprising administering by inhalation to a human suffering from pulmonary hypertension a therapeutically effective single event dose of a formulation comprising treprostinil or a pharmaceutically acceptable salt thereof with an inhalation device, wherein the therapeutically effective single event dose comprises from 15 micrograms to 90 micrograms of treprostinil or a pharmaceutically acceptable salt thereof delivered in 1 to 3 breaths.
2. The method of claim 1 , wherein the inhalation device is a soft mist inhaler.
3. The method of claim 1 , wherein the inhalation device is a pulsed ultrasonic nebulizer.
4. The method of claim 1 , wherein the inhalation device is a dry powder inhaler.
5. The method of claim 1 , wherein the inhalation device is a pressurized metered dose inhaler.
6. The method of claim 4 , wherein the formulation is a powder.
7. The method of claim 6 , wherein the powder comprises particles less than 5 micrometers in diameter.
8. The method of claim 1 , wherein the formulation contains no metacresol.