Light-emitting devices for wound healing
Methods and devices related to wound healing using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising Ring System 1, Ring System 2, Ring System 3, Ring System 4 or Ring System 5.
1. A light-emitting device for use in phototherapy comprising:
an anode;
a cathode; and
an organic light-emitting layer disposed between the anode and the cathode;
wherein the organic light-emitting-layer comprises an organic luminescent compound and a host;
wherein the organic luminescent compound is an iridium compound and has a peak emission between 620 nm and 640 nm;
wherein the device is configured to provide an amount of light from the light-emitting layer effective to treat a wound of a human with impaired wound healing resulting from diabetes; and
wherein the host is:
and wherein the device further comprises a dosage component comprising a timer coupled to a positioning component, wherein said dosage component is configured to deliver a light dose of 0.05 J/cm 2 to 15 J/cm 2 to a wound.
2. The device of claim 1 , wherein the device is configured to provide light to the wound at a power density of 2 mW/cm 2 to 20 mW/cm 2 .
3. The device of claim 1 , wherein the device is configured to provide light to the wound at a power density of 7 mW/cm 2 to 10 mW/cm 2 .
4. The device of claim 1 , wherein the device comprises a flexible substrate, and wherein the light-emitting layer comprises an organic light-emitting diode coupled to the flexible substrate.
5. The device of claim 1 , further comprising a capping layer disposed on the cathode.
6. A phototherapy system comprising:
a device according to claim 1 ; and,
a wound dressing comprising a flexible wrapping material and a hydrocolloid layer;
wherein the device of claim 1 is at least partially positioned between the flexible wrapping material and the hydrocolloid layer.
7. The phototherapy system of claim 6 wherein the dosage component is configured to deliver a light dose of 0.2 J/cm 2 to 5 J/cm 2 to the wound.
8. The phototherapy system of claim 6 , wherein the wound dressing comprises a hydrocolloid layer that is in direct contact with the device, wherein the phototherapy system is configured so that the hydrocolloid layer is disposed between the device and a wound when the phototherapy system is used to treat the wound.
9. The phototherapy system of claim 8 , further comprising an adhesive layer, wherein the phototherapy system is configured so that the adhesive layer is disposed between, and in contact with the, wound and the hydrocolloid layer when the phototherapy system is used to treat the wound.
10. A method of treating a wound comprising: exposing at least a portion of a wound to light from a system of claim 6 .
11. The method of claim 10 , wherein a light dose of 1 J/cm 2 to 5 J/cm 2 is delivered to the wound.
12. The method of claim 10 , wherein a light dose of 5 J/cm 2 is delivered to the wound.
13. The method of claim 10 , wherein the wound is treated from 2 days to 8 days after an injury.