IP Library › Granted Patent US 10,821,161
Granted Patent B2
US 10,821,161 · App. 15/533,153 · Granted Nov 3, 2020

CS1 targeted chimeric antigen receptor-modified T cells

Inventors: Xiuli Wang (Duarte, CA); Stephen J. Forman (Duarte, CA)
Assignee: City of Hope
A61K39/0011A61K35/17C07K14/35C07K14/705C07K14/7051C07K14/70521C07K14/71C07K16/2803C07K16/2896C12N5/0636C12N5/0637C12N5/0638A61K2039/5156A61K2039/5158C07K2317/526C07K2317/53C07K2317/622C07K2319/02C07K2319/03C07K2319/033C12N2510/00
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Quick Facts
Patent No.
US 10,821,161
App. No.
15/533,153
Granted
Nov 3, 2020
Kind
B2
Abstract

Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.

Claims (13)

1. A nucleic acid molecule encoding a polypeptide comprising the amino acid sequence of any of SEQ ID NOs: 29, 30, 31, 32, 33, 34, 38, 39, and 40.

2. The nucleic acid molecule of claim 1 , wherein the polypeptide comprises the amino acid sequence of any of SEQ ID NOs: 29, 30, and 31.

3. The nucleic acid molecule of claim wherein the polypeptide comprises the amino acid sequence of any of SEQ ID NOs: 32, 33, and 34.

4. The nucleic acid molecule of claim wherein the polypeptide comprises the amino acid sequence of any of SEQ ID NOs: 38, 39, and 40.

5. A population of human T cells transduced by a vector comprising an expression cassette encoding a polypeptide comprising the amino acid sequence of any of SEQ ID NOs: 29, 30, 31, 32, 33, 34, 38, 39, and 40.

6. The population of human T cells of claim 5 , wherein the polypeptide comprises the amino acid sequence of any of SEQ ID NOs: 29, 30, 31, 32, 33, 34, 38, 39, and 40.

7. The population of human T cells of claim 5 , wherein at least 20%, 30%, 40%, 50%, 60%, 70% or 80% of the transduced human T cells are central memory T cells.

8. The population of human T cells of claim 5 , wherein at least 10% or 20% of the transduced central memory T cells are CD4+.

9. The population of human T cells of claim 5 , wherein at least 10% or 20% of the transduced central memory T cells are CD8+.

10. The population of human T cells of claim 5 , wherein at least 10% of the central memory T cells are CD4+ and at least 10% are CD8+.

11. The population of human T cells of claim 5 , wherein the polypeptide comprises the amino acid sequence of any of SEQ ID NOs: 29, 30, and 31.

12. The population of human T cells of claim 5 , wherein the polypeptide comprises the amino acid sequence of any of SEQ ID NOs: 32, 33, and 34.

13. The population of human T cells of claim 5 , wherein the polypeptide comprises the amino acid sequence of any of SEQ ID NOs: 38, 39, and 40.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 12, 2017
From: WANG, XIULI; FORMAN, STEPHEN J.
To: CITY OF HOPE
Reel/Frame 043566/0558 →
Continuity (2)
Provisional Application 62088423 · Dec 5, 2014
Related Publication 20170360910A1 · Dec 21, 2017
Cited By (1)
US 12,497,440