High-purity quinoline derivative and method for manufacturing same
Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less.
1. A method for producing a compound represented by formula (IV)
or a salt thereof, comprising:
a step B of allowing a compound represented by formula (I)
or a salt thereof to react with the compound represented by formula (II-A)
wherein R 1 is a C 6-10 aryl group that may have one to three substituents that may be the same or different and are selected from the group consisting of a halogen atom, a methyl group, a methoxy group, and a nitro group; and X is a halogen atom,
in the presence of a base and water to thereby obtain a compound represented by formula (III)
wherein R 1 is the same group as above, and
a step C of, after allowing the compound represented by formula (III) obtained in the step B to react without isolation with cyclopropylamine, precipitating and isolating a compound represented by formula (IV)
or a salt thereof by introducing a hydrous organic solvent to a reaction solution.
2. The method according to claim 1 , wherein the amount of water is 1.0-1.5 equivalent against the compound represented by formula (I).
3. The method according to claim 2 , wherein the amount of water is one equivalent against the compound represented by formula (I).