Peptide for promoting regeneration of dentin or dental pulp tissue
Provided are a novel peptide, a polynucleotide encoding the peptide, an expression vector including the polynucleotide, and a pharmaceutical composition including the peptide, a quasi-drug composition including the peptide, and a health functional food composition including the peptide.
1. A method of treating dentin hypersensitivity and/or promoting regeneration of dentin or dental pulp tissues of a subject in need thereof, comprising administering to the subject a composition comprising one or more of the following (i)-(iii):
(i) a peptide comprising an amino acid sequence of the following Formula 1:
K—Y—R1-R2-R3-R4-R5-R6-R7-R8 (Formula 1)
wherein R1 is arginine(R), lysine(K), or glutamine(Q);
R2 is arginine(R) or glutamine(Q);
R3, R4, and R5 are arginine(R) or lysine(K), respectively:
R6 is asparagine(N) or serine(S); and
R7 and R8 are lysine(K) or tyrosine(Y), respectively,
(ii) a polypeptide compound prepared by linking repeats of the peptide (i), and
(iii) a complex of the peptide (i) linked to a drug having a therapeutic effect on dentin or dental pulp diseases.
2. The method of claim 1 , wherein the peptide of-(i) comprises any one of the amino acid sequences of SEQ ID NOS: 1 to 96.
3. The method of claim 2 , wherein the peptide (i) has a modification selected from the group consisting of N- or C-terminal acetylation, amidation, or methylation; D-amino acid introduction; peptide bond modification selected from the group consisting of CH 2 —NH, CH 2 —S, CH 2 —S═O, CH 2 —CH 2 ; backbone modification; and side-chain modification.
4. The method of claim 2 , wherein the composition is a pharmaceutical composition and further comprises a pharmaceutically acceptable carrier, excipient, or diluent.
5. The method of claim 2 , wherein the composition is a food.
6. The method of claim 2 , wherein the composition is an oral antiseptic mouthwash, oral hygiene product, toothpaste, dental floss, or oral ointment.
7. The method of claim 2 , wherein the composition comprises the peptide of (i) and the polypeptide of (ii).
8. The method of claim 2 , wherein the composition comprises the peptide of (i) and the complex of (iii).
9. The method of claim 1 , wherein the peptide (i) has a modification selected from the group consisting of N- or C-terminal acetylation, amidation, or methylation; D-amino acid introduction; peptide bond modification selected from the group consisting of CH 2 —NH, CH 2 —S, CH 2 —S═O, CH 2 —CH 2 ; backbone modification; and side-chain modification.
10. The method of claim 1 , wherein the composition is a pharmaceutical composition and further comprises a pharmaceutically acceptable carrier, excipient, or diluent.
11. The method of claim 1 , wherein the composition is a food.
12. The method of claim 1 , wherein the composition is an oral antiseptic mouthwash, oral hygiene product, toothpaste, dental floss, or oral ointment.
13. The method of claim 1 , wherein the composition comprises the peptide of (i) and the polypeptide of (ii).
14. The method of claim 1 , wherein the composition comprises the peptide of (i) and the complex of (iii).