IP Library › Granted Patent US 10,858,359
Granted Patent B2
US 10,858,359 · App. 16/307,827 · Granted Dec 8, 2020

Heterocyclic ring derivatives useful as SHP2 inhibitors

Inventors: Cunbo Ma (Beijing, CN); Panliang Gao (Beijing, CN); Jie Chu (Beijing, CN); Xinping Wu (Beijing, CN); Chunwei Wen (Beijing, CN); Di Kang (Beijing, CN); Jinlong Bai (Beijing, CN); Xiaoyan Pei (Beijing, CN)
Assignee: JACOBIO PHARMACEUTICALS CO., LTD.
C07D471/14A61P9/00A61P27/00A61P35/00A61P37/00C07D401/04C07D401/12C07D401/14C07D405/14C07D413/14C07D471/04C07D471/20C07D491/107C07D519/00
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Quick Facts
Patent No.
US 10,858,359
App. No.
16/307,827
Granted
Dec 8, 2020
Kind
B2
Abstract

Provided are certain novel pyrazine derivatives (I) as SHP2 inhibitors which is shown as formula (I), their synthesis and their use for treating a SHP2 mediated disorder. More particularly, provided are fused heterocyclic derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Claims (3)

1. A compound which is:

or a pharmaceutically acceptable salt thereof.

2. A compound which is:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 3, 2021
From: MA, CUNBO; GAO, PANLIANG; CHU, JIE; WU, XINPING; WEN, CHUNWEI; KANG, DI; BAI, JINLONG; PEI, XIAOYAN
To: JACOBIO PHARMACEUTICALS CO., LTD.
Reel/Frame 058280/0541 →
Priority Claims (1)
WO PCT/CN2016/085122 · Jun 7, 2016 · international
Continuity (1)
Related Publication 20190127378A1 · May 2, 2019
Cited By (3)
US 12,233,062 US 12,338,246 US 12,390,469