Granted Patent B2

US 12,233,062 · App. 18/591,753 · Granted Feb 25, 2025

Inventors: Huifeng Han (Beijing, CN); Panliang Gao (Beijing, CN); Cunbo Ma (Beijing, CN); Di Kang (Beijing, CN)

Assignee: Jacobio Pharmaceuticals Co., Ltd.

A61K31/497A61K31/438A61K31/444A61K31/4545A61K31/4985A61K31/501A61K31/506A61K31/513A61K31/519A61K31/53A61K31/5377C07D401/04C07D401/14C07D405/14C07D417/04C07D471/10C07D487/04C07D491/107C07D495/10C07D513/04C07D513/10C07D519/00C07B2200/05

Abstract

Claims (33)

1. A compound of Formula II:

II;

or a pharmaceutically acceptable salt thereof;

wherein:

represents a single bond or a double bond;

ring A is

ring B is

wherein * represents the connection point to G and ** represents the connection point to N;

G is S;

T is CR 1 R 2 ;

each of R 1 and R 2 is independently selected from hydrogen, deuterium, or —NH 2 ;

p is 1;

each of R 3 and R 4 is independently hydrogen or deuterium;

q is 1;

W is absent;

Y 5 is C;

Y 6 is C;

ring C is

R a is H; and

n is 0.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Ring A is

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein Ring B is

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is H, and R 2 is NH 2 .

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein ring C is

6. The compound of claim 2 , or a pharmaceutically acceptable salt thereof, wherein Ring B is

7. The compound of claim 6 , or a pharmaceutically acceptable salt thereof, wherein R 1 is H, and R 2 is NH 2 .

8. The compound of claim 7 , or a pharmaceutically acceptable salt thereof, wherein ring C is

9. A compound which is:

(S)-1-amino-1′-(6-((3-amino-2-chlorophenyl)thio)-1,2,4-triazin-3-yl)-1,3-dihydrospiro [indene-2,4′-piperidine]-6-carbonitrile; or

(S)-1′-(5-amino-6-((2-amino-3-chloropyridin-4-yl)thio)-1,2,4-triazin-3-yl)-5,7-dihydrospiro [cyclopenta [b]pyridine-6,4′-piperidin]-5-amine;

or a pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition comprising the compound of claim 1 , or pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

11. A pharmaceutical composition comprising the compound of claim 9 , or pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.

Assignments (1)

Priority Claims (1)

Continuity (5)

References Cited (297)